Bacteriostatic effect of serum: role of antibody to lipopolysaccharide.

Infection and Immunity
S P Fitzgerald, H J Rogers

Abstract

Previous work has shown that antibody and transferrin, acting together, exert a bacteriostatic effect on certain pathogenic Escherichia coli. This effect may be due to the ability of the antibody to interfere with the release of the iron chelator, enterochelin, from the bacterial cell. Enterochelin is essential for the transport of iron from transferrin to the bacterial cell. The nature of the bacterial antigen against which the antibody is directed has now been determined by means of adsorption experiments. It was found that absorption of serum either with hear-killed cells of E. coli O111 or with Boivin antigen abolished the bacteriostatic effect. A monosaccharide, which proved to be colitose (3,6-dideoxy-L-galactose), was isolated after acetic acid hydrolysis of the Boivin antigen. Colitose is the terminal monosaccharide of the O-specific side chain of the lipopolysaccharide from E. coli O111. This monosaccharide abolished the bacteriostatic effect of both whole serum and mixtures of antibody and iron-binding proteins. When administered by the intraperitoneal route, it reduced the resistance of mice to subsequent infection with E. coli O111. This ability of colitose to interfere with antibacterial mechanisms is in accord wit...Continue Reading

References

Apr 27, 1977·Biochimica Et Biophysica Acta·H J RogersP M Bayley
Apr 1, 1977·The Journal of Infectious Diseases·I KochanT I Wiles
Sep 1, 1977·Bacteriological Reviews·I OrskovK Jann
Mar 1, 1978·Microbiological Reviews·E D Weinberg
Sep 1, 1968·The Journal of Experimental Medicine·D N MedearisE C Heath
Mar 1, 1966·Bacteriological Reviews·O LüderitzO Westphal
Sep 9, 1950·Nature·W E TREVELYANJ S HARRISON
Mar 1, 1973·Infection and Immunity·H J Rogers

❮ Previous
Next ❯

Citations

Mar 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Fomsgaard, I A Holder
Oct 27, 2004·Infection and Immunity·Arturo Casadevall, Liise-anne Pirofski
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuemei XieJ Christopher Hall
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy J LaRoccaJorge L Benach
Feb 1, 1984·Infection and Immunity·I KochanJ Wasynczuk
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·J J HoogeterpR van Furth
Jan 1, 1983·Annales d'immunologie·D RivierH Isliker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.