Bacteriostatic properties of biomatrices against common orthopaedic pathogens

Biochemical and Biophysical Research Communications
Grace A CarlsonProsper Benhaim

Abstract

Tissue-engineered grafts for tissue regeneration include either mature or progenitor cells seeded onto biomatrices that provide shape and support for developing tissue. Popular biomaterials used in orthopaedic surgery include collagen type I, hyaluronic acid, hydroxyapatite, and polylactic polyglycolic acid (PLGA). Biomatrices with bacteriostatic properties may be beneficial in promoting tissue-engineered graft survival in patients susceptible to infection. We evaluated the bacteriostatic effects of these biomaterials on the growth of the four most common orthopaedic bacterial pathogens: Staphylococcus aureus, Staphylococcus epidermidis, beta-hemolytic Streptococcus, and Pseudomonas aeruginosa. Hyaluronic acid demonstrated the largest bacteriostatic effect on these pathogens by inhibiting bacterial growth by an average of 76.8% (p = 0.0005). Hydroxyapatite and collagen inhibited growth on average by 49.7% (p = 0.011) and 37.5% (p = 0.102), respectively. PLGA exhibited the least bacteriostasis with an average inhibition of 9.8% (NS) and actually accelerated the growth of beta-hemolytic Streptococcus and P. aeruginosa.

References

Apr 1, 1992·Matrix : Collagen and Related Research·U B LaurentT C Laurent
Jun 1, 1991·The Journal of Hospital Infection·P J Sanderson
May 24, 1985·Science·A G GristinaC D Hobgood
Jul 1, 1984·The American Journal of Medicine·R D InmanC L Christian
Dec 1, 1994·Archives of Biochemistry and Biophysics·D G PritchardJ R Baker
Aug 4, 1998·Acta Odontologica Scandinavica·P StoorJ I Salonen
May 18, 1999·Journal of Periodontology·P PirnazarG W Bernard
Jul 6, 2000·The Orthopedic Clinics of North America·J E FlemingG F Muschler
Jul 6, 2000·The Orthopedic Clinics of North America·S N KhanJ M Lane
Aug 11, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H C VogelyA J Verbout
Sep 25, 2001·The Journal of Hospital Infection·J M Schierholz, J Beuth
Mar 12, 2002·Tissue Engineering·Ayda SarikayaMichael Ladisch
Apr 12, 2002·Journal of Biomedical Materials Research·Masato UeshimaKimihiro Yamashita
May 20, 1996·Biotechnology and Bioengineering·S L IshaugA G Mikos

❮ Previous
Next ❯

Citations

Oct 25, 2007·Journal of Materials Science. Materials in Medicine·J VenugopalS Ramakrishna
Sep 6, 2011·Journal of Materials Science. Materials in Medicine·Andrea ArdizzoniElisabetta Blasi
Mar 20, 2010·Tissue Engineering. Part a·Andrew P PriceAngela Panoskaltsis-Mortari
Mar 24, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·J VenugopalS Ramakrishna
Jan 22, 2009·Journal of Biomaterials Science. Polymer Edition·Suzana JusGeorg M Guebitz
Mar 29, 2011·Virology Journal·Claudio CermelliBeniamino Palmieri
Sep 7, 2013·The Journal of Hospital Infection·C DesrousseauxO Traoré
Mar 19, 2013·Journal of Biomedical Materials Research. Part a·Amaliris RuizKristyn S Masters
Sep 28, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·D Alves CardosoS C G Leeuwenburgh
Feb 3, 2015·Journal of Clinical Periodontology·Kristina BertlAndreas Stavropoulos
Apr 5, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lorenzo DragoRoberto Mattina
Aug 19, 2015·Biochemical and Biophysical Research Communications·Ningbo ZhaoDehua Li
Mar 24, 2016·Journal of Biomedical Materials Research. Part a·Ningbo ZhaoDehua Li
Apr 26, 2016·Acta Biomaterialia·Margaret E CassinPadmavathy Rajagopalan
Jun 3, 2016·Clinical Oral Implants Research·Kristina BertlAndreas Stavropoulos
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Sep 22, 2018·PloS One·Tara D SutherlandGavin A Huttley
Nov 30, 2006·Journal of Biomedical Materials Research. Part a·Zhongkui HongXiabin Jing
Aug 9, 2019·American Journal of Respiratory and Critical Care Medicine·Airan LiuJae-Woo Lee
May 23, 2017·Journal of Bone and Joint Infection·C L RomanòL Drago
Jan 10, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stavros GarantziotisLorenzo Drago
May 6, 2019·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Kathryn Y BurgeHala Chaaban
Mar 14, 2021·Carbohydrate Polymers·Fernanda ZamboniMaurice N Collins
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Yuwei YangHongwei Ouyang
Jul 10, 2017·ACS Biomaterials Science & Engineering·Pedro S BaboManuela E Gomes
Sep 16, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiwen ZhangJae-Woo Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2021 Meta ULC. All rights reserved