PMID: 11929561Apr 4, 2002Paper

Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose

Oral Microbiology and Immunology
Y MurakamiF G Oppenheim

Abstract

Bacteroides forsythus, which has been recognized as a pathogen associated with periodontitis, produces a hemagglutinin. The hemagglutinin was localized in the envelope of B. forsythus. The hemagglutinating activity was inhibited by lactose at concentrations as low as 1 mM, and by L-arginine and L-lysine at concentrations of 100 mM. N-Acetylneuraminyllactose (NeuAc-lactose) was at least 100 times more potent an inhibitor than lactose, as it completely inhibited the hemagglutination at concentrations below 10 microM. This is similar to the Helicobacter pylori hemagglutinin. The hemagglutinin was heat-labile, and resistant to treatment with proteases such as trypsin. A specific antibody raised against one of the S-layer proteins that are major species-specific proteins had no inhibitory effect on the hemmaglutination. These results suggest that the NeuAc-lactose-sensitive adhesin of B. forsythus may play an important role in colonization in the oral cavity.

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Citations

Oct 5, 2010·Molecular Oral Microbiology·V BakthavatchaluL Kesavalu
Apr 26, 2013·Clinical and Vaccine Immunology : CVI·Gerald PoschChristina Schäffer
Mar 30, 2013·Archives of Oral Biology·Hidetomo OnishiKitetsu Shin
Aug 26, 2006·Periodontology 2000·Anne C R Tanner, Jacques Izard
Aug 18, 2010·Periodontology 2000·Ashu Sharma
Jul 12, 2016·Archives of Oral Biology·Hidetomo OnishiKitetsu Shin
Jan 1, 2012·Biomolecules·Gerald PoschChristina Schäffer

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