Bactobilia after liver transplantation: frequency and antibiotic susceptibility

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Gunda MillonigWolfgang Vogel

Abstract

After liver transplantation (LT), bactobilia occurs frequently in patients, leading in some cases to cholangitis and biliary sepsis. The present study is the first to investigate bactobilia after LT, and it gives an overview of predisposing factors for bactobilia, the microbial spectrum in the bile of LT patients, and the antibiotic susceptibility. A total of 172 endoscopic retrograde cholangiography (ERC) procedures were performed in 66 LT patients between 1 month and 5.8 years after LT. Bile samples were examined microbiologically. Sixty-eight nontransplanted patients without cholestasis, but requiring ERC for other reasons served as a control group. Of 172 samples obtained from LT patients, 126 (73.3%) were positive for microbes. A total of 236 organisms were isolated: 114 (48.3%) gram-positive bacteria, 92 (39.0%) aerobic gram-negative, 8 (3.4%) anaerobes, and 22 (9.3%) fungi. Ciprofloxacin and amoxycillin/clavulanic acid showed the best susceptibility results among oral antibiotics and piperacillin/tazobactam and imipenem/cilastatin among intravenous preparations. In contrast, only 15.7% of non-LT patients showed bactobilia. In conclusion, our study shows that bactobilia is a problem in patients after LT and that it is not...Continue Reading

References

Sep 1, 1992·Antimicrobial Agents and Chemotherapy·J W LeungG L French
May 1, 1992·Digestive Diseases and Sciences·J Y SungE A Shaffer
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Sanchez-UrdazpalR A Krom
Jul 1, 1991·Digestive Diseases and Sciences·J Y SungJ W Costerton
Nov 1, 1991·Gastroenterology·S MotteM Cremer
May 1, 1989·Journal of Clinical Microbiology·J W LeungJ W Costerton
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·M F ParryM A Digiovanni
Nov 1, 1987·Antimicrobial Agents and Chemotherapy·A L GrazianiR R MacGregor
Aug 1, 1982·British Journal of Clinical Pharmacology·D P MaudgalR N Wild
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B BylM Cremer
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Sanchez-UrdazpalR A Krom
Nov 1, 1996·Antimicrobial Agents and Chemotherapy·S J van den HazelD J van Leeuwen
Sep 14, 1999·The American Journal of Gastroenterology·C Y ChenX Z Lin
Aug 18, 2000·Clinical Transplantation·T D JohnstonD Ranjan
Feb 24, 2001·Digestive Diseases and Sciences·T NomuraK Hatakeyama
Aug 2, 2001·The Journal of Antimicrobial Chemotherapy·R ReckziegelL Z Goldani
Jul 4, 2002·The Journal of Antimicrobial Chemotherapy·Peter GilbertSally F Bloomfield
Oct 8, 2003·Transplantation Proceedings·W PatkowskiM Krawczyk

❮ Previous
Next ❯

Citations

May 7, 2013·Abdominal Imaging·Jason N ItriMitchell E Tublin
Nov 26, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Daniel BentenMartina Sterneck
Jul 25, 2012·World Journal of Gastroenterology : WJG·Muhsin KayaMehmet Ali Kaplan
Nov 21, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Onofrio A CatalanoPeter F Hahn
Sep 25, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M HashimotoM Makuuchi
May 22, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D VrochidesP E Morrissey
Apr 23, 2014·Current Opinion in Organ Transplantation·Christian van Delden
Aug 6, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Henrik H JungerStefan M Brunner
Jun 28, 2017·World Journal of Gastroenterology : WJG·Anna Hüsing-KabarIyad Kabar
Apr 5, 2019·Journal of Clinical and Translational Hepatology·Brian T Moy, John W Birk
Jun 14, 2019·Gastroenterology Research and Practice·Hua-Qiang RuanJie-An Huang
Nov 11, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bianca LascarisVincent E de Meijer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.