Baculovirus-Encoded MicroRNAs: A Brief Overview and Future Prospects

Current Microbiology
Qi TangGuohui Li

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs with ∼22 nucleotides, which are able to regulate various biological processes, including the viral life cycle and host-pathogen interactions. Long primary transcripts (pri-miRNAs) are initially transcribed in nucleus, and subsequently processed by Dicer in cytoplasm to generate mature miRNAs. Baculoviruses consist of large, enveloped, insect-pathogenic viruses with a double-stranded circular DNA genome. Recent studies suggest that baculoviruses encode some miRNAs to manipulate expression regulation of host genes, whereas host modulate viral gene expression via miRNAs to limit viral infection. In the review, we will focus on the biogenesis and functions of miRNAs and the interactions between baculoviruses, insect, and miRNAs. It will be helpful to delve into the related mechanisms of BmNPV-encoded miRNAs that contribute to infection and pathogenesis.

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Citations

Aug 7, 2018·Investigational New Drugs·Chongchong WangLi Cheng
Apr 10, 2019·International Journal of Endocrinology·Xi SunXianghang Luo
May 25, 2021·Frontiers in Physiology·Mian Muhammad AwaisJingchen Sun

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Methods Mentioned

BETA
CLASH

Software Mentioned

Srnaloop
BLASTn

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