PMID: 9529073Apr 7, 1998Paper

Baculovirus merozoite surface protein 1 C-terminal recombinant antigens are highly protective in a natural primate model for human Plasmodium vivax malaria

Infection and Immunity
K L PereraK Mendis

Abstract

A successful anti-blood stage malaria vaccine trial based on a leading vaccine candidate, the major merozoite surface antigen-1 (MSP1), is reported here. The trial was based on Plasmodium cynomolgi, which is a primate malaria parasite which is highly analogous to the human parasite Plasmodium vivax, in its natural host, the toque monkey, Macaca sinica. Two recombinant baculovirus-expressed P. cynomolgi MSP1 proteins, which are analogous to the 42- and 19-kDa C-terminal fragments of P. falciparum MSP1, were tested by immunizing three groups of three animals each with either p42, p19, or both together. The vaccines were delivered subcutaneously in three doses at 4-week intervals with complete and incomplete Freund's adjuvants. Very high antibody titers were obtained against both vaccinating antigens as measured by enzyme-linked immunosorbent assay (10[6] and above) and against whole parasites as measured by indirect immunofluorescence assay (>10[5]), achieving, in most animals, about a 10-fold increase from the first to the last immunization. A blood stage challenge with P. cynomolgi parasites led, in three adjuvant-treated and three naive control animals, to blood infections which were patent for at least 44 days, reaching peak ...Continue Reading

References

Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·G J SchuurkampK H Rieckmann
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·P L Garavelli, E Corti
Jan 1, 1991·Molecular and Biochemical Parasitology·X D FangL H Miller
Mar 1, 1991·The Journal of Experimental Medicine·T S NaotunneK N Mendis
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H A del PortilloP H David
Jul 1, 1988·The American Journal of Tropical Medicine and Hygiene·J S PeirisK N Mendis
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·R L Ihalamulla, K N Mendis
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W A SiddiquiS C Kan
Jun 1, 1982·The Australian and New Zealand Journal of Surgery·D R Hamilton, D Pikacha
Apr 1, 1994·Molecular and Biochemical Parasitology·S LongacreP H David
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·A A Escalante, F J Ayala
Feb 1, 1994·Parasite Immunology·I T LingA A Holder
Oct 1, 1993·Molecular and Biochemical Parasitology·G SnounouK N Brown
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·M GargN A Kshirsagar
Dec 1, 1996·Tropical Medicine & International Health : TM & IH·V K DuaV P Sharma
Feb 1, 1993·Parasitology Today·J A Cooper
Aug 1, 1993·Parasitology Today·C L DiggsL H Miller

❮ Previous
Next ❯

Citations

Jun 28, 2001·The Journal of Parasitology·R S Desowitz
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiraprapa WipasaMichael F Good
Aug 9, 2005·Expert Opinion on Emerging Drugs·W Ripley Ballou
May 7, 2009·Immunology and Cell Biology·Jack S Richards, James G Beeson
Jan 6, 2010·Infection and Immunity·Leonie M van DuivenvoordeAlan W Thomas
Sep 4, 2012·International Journal of Molecular Sciences·Nicola ClementiRoberto Burioni
Nov 1, 2009·Expert Opinion on Drug Discovery·Satoru TakeoTakafumi Tsuboi
Oct 24, 2019·Immunological Reviews·Lis R AntonelliRicardo T Gazzinelli
Jan 27, 2006·World Journal of Gastroenterology : WJG·Zhi-Hong ZhangWeida Huang
May 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita M DreyerGerd Pluschke
May 24, 2011·Journal of Parasitology Research·Daniel Y BargieriMauricio M Rodrigues
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alan F CowmanBrendan S Crabb
Feb 20, 2009·Malaria Journal·Mary R Galinski, John W Barnwell
Feb 27, 2001·Current Opinion in Hematology·C E Chitnis
Sep 13, 2002·Immunology and Cell Biology·Jiraprapa WipasaMichael F Good
Jan 23, 2021·Expert Review of Vaccines·Sai Lata DeJohn H Adams
Nov 18, 2005·The American Journal of Tropical Medicine and Hygiene·Augusto Valderrama-AguirreSócrates Herrera
Aug 26, 1999·Vaccine·C I de OliveiraH A del Portillo
Jun 5, 2003·International Journal for Parasitology·John P DaltonAlex Loukas
Aug 21, 2007·Molecular and Biochemical Parasitology·Kazuyuki TanabeHirohisa Kishino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.