Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma

Pigment Cell & Melanoma Research
Filipe V AlmeidaAshani T Weeraratna

Abstract

This review will focus on the role of the tumor microenvironment (TME) in the development of drug resistance in melanoma. Resistance to mitogen-activated protein kinase inhibitors (MAPKi) in melanoma is observed months after treatment, a phenomenon that is often attributed to the incredible plasticity of melanoma cells but may also depend on the TME. The TME is unique in its cellular composition-it contains fibroblasts, immune cells, endothelial cells, adipocytes, and among others. In addition, the TME provides "non-homeostatic" levels of oxygen, nutrients (hypoxia and metabolic stress), and extracellular matrix proteins, creating a pro-tumorigenic niche that drives resistance to MAPKi treatment. In this review, we will focus on how changes in the tumor microenvironment regulate MAPKi resistance.

References

Oct 1, 1991·British Journal of Cancer·W H Clark
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Mar 22, 2002·The Lancet Oncology·Dirk RuiterMeenhard Herlyn
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfonso BaldiMarco G Paggi
Oct 18, 2005·Immunity·Alberto MantovaniMassimo Locati
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Jun 28, 2006·The Journal of Experimental Medicine·Hidetoshi SumimotoYutaka Kawakami
Dec 22, 2006·Genes & Development·Suzanne CarreiraColin R Goding
Sep 6, 2007·Cancer Cell·Ping GaoChi V Dang
Nov 10, 2007·Melanoma Research·Hanneke G M Wittgen, Léon C L T van Kempen
Mar 19, 2008·Immunology·Dorothy K SojkaDeborah J Fowell
May 24, 2008·International Journal of Cosmetic Science·S DiridollouF Patat
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Sep 11, 2009·Journal of Leukocyte Biology·G SolinasP Allavena
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Aug 24, 2010·Pigment Cell & Melanoma Research·Keith S Hoek, Colin R Goding
Oct 27, 2010·Pigment Cell & Melanoma Research·John T LeeMeenhard Herlyn
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nikhil WagleLevi A Garraway
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erez FeigeDavid E Fisher
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Eric A KleinLaurence H Baker
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James S WilmottRichard A Scolyer
Feb 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David S HongPatrick Hwu
May 16, 2012·Journal of the American Academy of Dermatology·Katherine A WardMaria K Hordinsky
Jul 20, 2012·Journal of Oncology·Gérald E PiérardPhilippe Delvenne
Jul 24, 2012·Cell·Eran HodisLynda Chin
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jahan S KhaliliGregory Lizée
Nov 13, 2012·Clinical & Experimental Metastasis·Chie Kudo-SaitoYutaka Kawakami
Nov 16, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva SchleckerAdelheid Cerwenka
Dec 18, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Sine HadrupPer Thor Straten
Jan 17, 2013·The Journal of Investigative Dermatology·Sebastian HaferkampSvenja Meierjohann
Mar 5, 2013·The Journal of Clinical Investigation·Deborah A KnightMark J Smyth
Mar 12, 2013·The Journal of Investigative Dermatology·Daniel S WidmerMitchell P Levesque

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Citations

Oct 3, 2019·Genes & Development·Florian RambowColin R Goding
Oct 30, 2019·Apoptosis : an International Journal on Programmed Cell Death·Aleksandra Mielczarek-LewandowskaMalgorzata Czyz
Jun 25, 2020·Cancers·Paolo BeccoMassimo Aglietta
Jan 9, 2019·Frontiers in Immunology·Chunmei Fu, Aimin Jiang
Dec 15, 2019·Nature Reviews. Cancer·Mitchell Fane, Ashani T Weeraratna
Nov 6, 2020·Médecine sciences : M/S·Margaux LecacheurSophie Tartare-Deckert
May 20, 2020·Seminars in Cancer Biology·Elena ObradorJosé M Estrela
Jul 18, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nuray ErinThomas Efferth
May 10, 2021·Journal of Experimental & Clinical Cancer Research : CR·Simona D'AguannoAntonietta Moramarco
Jun 3, 2021·Life·Jiri Vachtenheim, Lubica Ondrušová

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