Bad seeds produce bad crops: a single stage-process of prostate tumor invasion.

International Journal of Biological Sciences
Yan-gao Man, William A Gardner

Abstract

It is a commonly held belief that prostate carcinogenesis is a multi-stage process and that tumor invasion is triggered by the overproduction of proteolytic enzymes. This belief is consistent with data from cell cultures and animal models, whereas is hard to interpret several critical facts, including the presence of cancer in "healthy" young men and cancer DNA phenotype in morphologically normal prostate tissues. These facts argue that alternative pathways may exist for prostate tumor invasion in some cases. Since degradation of the basal cell layer is the most distinct sign of invasion, our recent studies have attempted to identify pre-invasive lesions with focal basal cell layer alterations. Our studies revealed that about 30% of prostate cancer patients harbored normal appearing duct or acinar clusters with a high frequency of focal basal cell layer disruptions. These focally disrupted basal cell layers had significantly reduced cell proliferation and tumor suppressor expression, whereas significantly elevated degeneration, apoptosis, and infiltration of immunoreactive cells. In sharp contrast, associated epithelial cell had significantly elevated proliferation, expression of malignancy-signature markers, and physical conti...Continue Reading

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Citations

Apr 4, 2009·International Journal of Biological Sciences·Aijun LiuYan-Gao Man
Aug 4, 2011·Journal of Cancer·Yan-Gao ManAlexander Stojadinovic
Apr 12, 2011·Journal of Surgical Oncology·Hangwen Li, Dean G Tang
Aug 27, 2014·Asia-Pacific Journal of Clinical Oncology·Henry Hi YaoFarshad Foroudi

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Methods Mentioned

BETA
biopsy

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