"Bad things come in small packages ": predicting venom-induced coagulopathy in Bothrops atrox bites using snake ontogenetic parameters

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Jorge Carlos Contreras BernalWuelton Marcelo Monteiro

Abstract

Introduction: Snake venom composition shows significant inter- and intra-species variation. In the case of the viperid species Bothrops atrox, responsible for the majority of snakebites in the Amazon region, geographical and ontogenetic variables affect venom composition, with ecological and medical implications. Previous studies had shown that venom from neonate and juvenile Bothrops specimens have a higher in vitro coagulant activity. The aim of this investigation was to assess the association of clinical outcomes, such as venom-induced coagulopathy and local complications, with B. atrox ontogenetic variables. Methods: This study explored the relationship between some clinical parameters in patients suffering envenomations by B. atrox in the Amazon and several morphometric parameters of the snake specimens causing the bites. Results: There were 248 specimens confirmed as agents of envenomation, mostly female snakes (70.5%) and classified as juveniles (62.7%). Patients bitten by neonates compared to adult snakes [OR = 2.70 (95%CI 1.15-6.37); p = .021] and by snakes with white tail tip [OR = 1.98 (95%CI 1.15-3.41); p = .013] were more likely to develop coagulopathy. Time from patient admission to the unclottable blood reversion...Continue Reading

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Jan 27, 2021·Toxicon : Official Journal of the International Society on Toxinology·Êndila de Souza BarbosaJacqueline de Almeida Gonçalves Sachett
Oct 28, 2020·Toxins·Manuela B PuccaWuelton M Monteiro
Mar 5, 2021·PLoS Neglected Tropical Diseases·Joseir Saturnino CristinoJacqueline Almeida Gonçalves Sachett
Mar 4, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Flavio Souza SilvaAllyson Guimarães Costa
Aug 22, 2020·Toxicon : Official Journal of the International Society on Toxinology·Tamires Nascimento da CostaPaulo Sérgio Bernarde
May 28, 2021·Toxicology Letters·Caroline Fabri Bittencourt RodriguesBryan G Fry

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