BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion.

Cellular Immunology
Mitchell ThornLinda A Spatz

Abstract

Overexpression of BAFF is believed to play an important role in systemic lupus erythematosus and elevated levels of serum BAFF have been found in lupus patients. Excess BAFF also leads to overproduction of anti-dsDNA antibodies and a lupus-like syndrome in mice. In the present study, we use mice transgenic for the R4A-Cmu (IgM) heavy chain of an anti-dsDNA antibody, to study the effects of BAFF overexpression on anti-dsDNA B-cell regulation. We observe that overexpression of BAFF promotes anti-dsDNA B-cell maturation and secretion of antibody and enriches for transgenic anti-dsDNA B cells in the marginal zone and follicular splenic compartments. In addition, our data suggests that BAFF rescues a subset of anti-dsDNA B cells from a regulatory checkpoint in the transitional stage of development.

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Citations

May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yusuke KishiTakeshi Tsubata
Feb 19, 2016·Nature Reviews. Rheumatology·Michael R Ehrenstein, Charlotte Wing
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