BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression.

Oncology Reports
Shutaro HabataTsuyoshi Saito

Abstract

Approximately 30% of uterine corpus carcinomas are diagnosed at an advanced stage and have a poor prognosis. Our previous study indicated that BCL2-associated athanogene 3 (BAG3) enhances matrix metalloproteinase-2 (MMP2) expression and binds to MMP2 to positively regulate the process of cell invasion in ovarian cancer cells. Recently, altered miRNA expression patterns were observed in several groups of patients with endometrial cancers. One of the altered miRNAs, miR-29b, reportedly reduces tumor invasiveness by suppressing MMP2 expression. Our aim in the present study was to examine the relationships among BAG3, miR-29b and MMP2 in endometrioid adenocarcinoma cells. We found that BAG3 suppresses miR-29b expression and enhances MMP2 expression, which in turn increases cell motility and invasiveness. Moreover, restoration of miR-29b through BAG3 knockdown reduced MMP2 expression, as well as cell motility and invasiveness. Collectively, our findings indicate that BAG3 enhances MMP2 expression by suppressing miR-29b, thereby increasing the metastatic potential of endometrioid adenocarcinomas.

References

Jan 1, 1993·Annual Review of Cell Biology·W G Stetler-StevensonL A Liotta
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Gianluigi GiannelliSalvatore Antonaci
Oct 31, 2002·Cancer Letters·Howard DoongElise C Kohn
Aug 29, 2006·The American Journal of Pathology·Sachiko HommaShinichi Takayama
Apr 4, 2007·Oncogene·J L MottG J Gores
May 23, 2007·Journal of Cell Science·Massimo NegriniCarlo M Croce
Nov 3, 2007·Cancer Research·Masahiro IwasakiShinichi Takayama
Dec 17, 2008·Molecular Cancer Therapeutics·Kristen M Nelson, Glen J Weiss
Feb 28, 2009·EMBO Reports·Christoph A GebeshuberJavier Martinez
Jul 10, 2009·Expert Opinion on Pharmacotherapy·Nicanor I Barrena MedelThomas J Herzog
Oct 24, 2009·Blood·Ramiro GarzonCarlo M Croce
Jun 22, 2010·Journal of Cellular Biochemistry·Justin L MottMartin E Fernandez-Zapico
Jul 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian-Hong FangShi-Mei Zhuang
Jan 30, 2013·European Journal of Cell Biology·Yang WangXiubao Ren
Feb 6, 2013·International Journal of Clinical Oncology·Kouji BannoDaisuke Aoki
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal

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Citations

Feb 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong WangJindan An
Oct 31, 2016·Journal of Cellular Physiology·Veronica EspositoMaurizio Guida
Apr 11, 2017·International Journal of Oncology·Carlos Palma FloresCésar López-Camarillo
May 26, 2018·Journal of Cellular Physiology·Anna De BlasioRiccardo Di Fiore
May 15, 2021·Journal of Cellular Biochemistry·Heng LinGail V W Johnson
Jun 9, 2021·British Journal of Cancer·Margot De MarcoLiberato Marzullo

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