Bahamaolides A and B, antifungal polyene polyol macrolides from the marine actinomycete Streptomyces sp

Journal of Natural Products
Dong-Gyu KimDong-Chan Oh

Abstract

Bahamaolides A and B (1 and 2), two new 36-membered macrocyclic lactones, were isolated from the culture of the marine actinomycete Streptomyces sp. derived from a sediment sample collected at North Cat Cay in the Bahamas. The planar structures of 1 and 2, bearing a hexaenone and nine consecutive skipped hydroxy groups, were determined by 1D and 2D NMR, mass, IR, and UV spectra. The absolute configurations of the bahamaolides were established by combined multistep chemical reactions and spectroscopic analysis. Bahamaolide A displayed significant inhibitory activity against Candida albicans isocitrate lyase and antifungal activity against various pathogenic fungi.

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Citations

Aug 22, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Teodor Parella, Juan Félix Espinosa
Feb 25, 2014·Applied Microbiology and Biotechnology·Randy Chi Fai CheungTzi Bun Ng
Feb 18, 2015·Applied Microbiology and Biotechnology·Jingbo TangYang Zhang
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Jul 22, 2020·Archives of Pharmacal Research·Cong WangShugeng Cao
Aug 23, 2021·Chinese Journal of Natural Medicines·Fu-Juan SunMing-Hua Yang
Aug 28, 2021·Biomedicines·Rodion KhotimchenkoYuri Khotimchenko

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