Baicalein Attenuates Lung Injury Induced by Myocardial Ischemia and Reperfusion

The American Journal of Chinese Medicine
Chang-Chi LaiCheng-Hsiung Huang

Abstract

Baicalein is an active component of Scutellaria baicalensis Georgi, which has traditionally been used to treat cardiovascular diseases in China. In this study, we investigated if treatment with baicalein can attenuate the lung injury induced by myocardial ischemia and reperfusion (I/R). Myocardial I/R, induced by a 40-min occlusion of the left anterior descending coronary artery and a 3-h reperfusion, significantly increased histological damage and the wet-to-dry weight ratio of lungs in rats. The terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive nuclei and caspase-3 activation was significantly increased in the lungs. Serum and bronchoalveolar lavage fluid levels of tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and interleukin-6 (IL-6) were significantly elevated, as were TNF-[Formula: see text] levels in the lung. Intravenous administration with baicalein at doses of 3, 10, and 30[Formula: see text]mg/kg for ten minutes before myocardial I/R significantly reduced histological damage, the wet-to-dry weight ratio, and apoptosis in the lung. Baicalein also significantly inhibited the increase in levels of TNF-[...Continue Reading

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Citations

Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kicinska, Wieslawa Jarmuszkiewicz
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Tao ZhangJiliang Wang
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Jan 19, 2021·BioMed Research International·Junjun YaoXiaozhong Lan

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