Abstract
Osteosarcoma (OS), a common and primary malignant bone tumor, is characterized by highly aggressive potency. Baicalein, a bioactive flavone isolated from Scutellaria baicalensis Georgi, has been shown to inhibit the progression of numerous tumors, including OS. However, the mechanisms by which baicalein protects against OS are still largely unknown. The results of the present study showed that administration of baicalein significantly inhibited the proliferation, migration and invasion and promoted apoptosis in MG‑63 and Saos‑2 cells. Ezrin was identified as a target gene of microRNA (miR)‑183. MG‑63 and Saos‑2 cells treated with baicalein exhibited increased miR‑183 levels and decreased Ezrin expression. Importantly, miR‑183 inhibition and Ezrin overexpression abolished the effects of baicalein on MG‑63 and Saos‑2 cell proliferation, migration, invasion and apoptosis. Taken together, these findings suggest that baicalein inhibits the proliferation, migration and invasion and induces apoptosis in OS cells by activating the miR‑183/Ezrin pathway, revealing a novel mechanism underlying anti‑OS effects of baicalein.
References
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 25, 2012·The American Journal of Pathology·Junfeng ZhuLiantang Wang
Aug 28, 2012·International Journal of Molecular Medicine·Haien ZhaoQingyu Fan
Jun 25, 2013·Gene·Qing-He ZhangFen Huang
Nov 5, 2013·BMC Cancer·Jienan KongZhenhua Lin
Dec 20, 2013·Medical Oncology·Yisila MuKun Li
Dec 30, 2014·TheScientificWorldJournal·Da-Hang ZhaoYong-Ming Wang
Jan 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fangfan YeJia Huang
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jian ZhangWen-Jun Wang
Feb 18, 2015·Biochemical and Biophysical Research Communications·Heesung ChungEok-Soo Oh
Feb 27, 2015·Molecular and Cellular Therapies·Molly A Taylor, William P Schiemann
Apr 22, 2015·Molecular and Cellular Biochemistry·Nengbin He, Zhichang Zhang
Jun 13, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Asmaa G AbdouAmal F Abd Eldayem
Nov 29, 2015·The Orthopedic Clinics of North America·Megan E Anderson
Dec 15, 2015·Advances in Experimental Medicine and Biology·Mary Nugent
Mar 24, 2016·Oncotarget·Jing LiYa Zhang
May 5, 2016·Drug Design, Development and Therapy·Xingcong MaShuqun Zhang
Jun 14, 2016·Biochemistry. Biokhimii︠a︡·N E KushlinskiiE A Braga
Aug 11, 2016·Annals of Hematology·Xiaoping LiuShangqin Liu
Aug 31, 2016·International Journal of Oncology·Eun-Ok ChoiYung Hyun Choi
Oct 21, 2016·Journal of Bone Oncology·Eugenio Zoni, Gabri van der Pluijm
Dec 23, 2016·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Ying GaoYi Charlie Chen
Jan 22, 2017·Neurochemical Research·Ning WeiLinlin Pang
Mar 6, 2017·Oncology Reports·Yuxia ChaiBaojun Yan
Mar 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaia PalminiMaria Luisa Brandi
Mar 14, 2017·European Journal of Medicinal Chemistry·Biswanath DindaManikarna Dinda
Mar 30, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M LiS Q Fang
Jun 1, 2017·Molecular Medicine Reports·Haiqiong YeXiaolan Yu
Sep 17, 2017·Oncotarget·Rong-Tao ZhouChun-Bo Teng
Nov 22, 2017·Oncotarget·Guo DaiWeichun Guo