Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line

Acta Biochimica Et Biophysica Sinica
Zhe ZhangWenwu Cheng

Abstract

Vasculogenic mimicry (VM) refers to a new tubular network of the blood supply system with abundant extracellular matrix. VM is similar to capillaries but does not involve endothelial cells. As a traditional herbal medicine commonly used in China, baicalein possesses anti-inflammatory and lipoxygenase activities. However, the effects of baicalein on the process of VM formation in non-small cell lung cancer (NSCLC) and the underlying mechanisms have remained poorly understood. In this study, baicalein was found to inhibit the viability and motility of A549 cells and induced the breakage of the cytoskeletal actin filament network. In addition, baicalein significantly decreased the formation of VM and downregulated the expressions of VM-associated factors, such as VE-cadherin, EphA2, MMP14, MMP2, MMP9, PI3K and LAMC2, similar to the effects of ROCK inhibitors. Indeed, baicalein inhibited RhoA/ROCK expression in vitro and in vivo, suggesting the underlying mechanisms of reduced VM formation. Collectively, baicalein suppressed the formation of VM in NSCLC by targeting the RhoA/ROCK signaling pathway, indicating that baicalein might serve as an emerging drug for NSCLC.

References

Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 3, 2009·Leukemia·P MirshahiM Mirshahi
Aug 2, 2011·Toxicology and Applied Pharmacology·Yung-Wei ChiuHsing-Chun Kuo
Jan 20, 2012·Cancer Biology & Therapy·Shi-yong WangYi-quan Ke
Apr 18, 2013·International Journal of Molecular Sciences·Zachary C Dobbin, Charles N Landen
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ling-Qiang ZhangChang Liu
Jul 3, 2013·Journal of Cellular and Molecular Medicine·Dan SunRan Sun
Nov 28, 2013·Cellular and Molecular Life Sciences : CMLS·Arun Murali, Krishnaraj Rajalingam
Aug 16, 2014·Human Pathology·Ke RenXiaoliang Sun
Jan 20, 2015·Journal of Cellular and Molecular Medicine·Lili QiaoYuan Tian
Nov 13, 2015·Critical Reviews in Eukaryotic Gene Expression·Srishti Kotiyal, Susinjan Bhattacharya
Dec 5, 2015·Frontiers in Pharmacology·Svenja HartmannSusanne Lutz
Dec 10, 2015·International Journal of Oncology·Dongjun JeongMoo Jun Baek
Mar 5, 2016·International Journal of Cancer. Journal International Du Cancer·S Krishna PriyaT S Ganesan
Mar 31, 2016·Journal of Cellular and Molecular Medicine·Qiqi LiuJiandong Zhang
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuixian LiXiuzhen Han
Sep 3, 2016·BMC Cancer·Mary-Clare CathcartGraham P Pidgeon
Dec 23, 2016·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Ying GaoYi Charlie Chen
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fei ShiXi-Qing Sun
Mar 6, 2017·Oncology Reports·Yuxia ChaiBaojun Yan
Mar 23, 2017·Molecular Cancer·Daniel Delgado-BellidoF Javier Oliver
Apr 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meiling YuXiaolin Liu
Jul 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beibei BieZongfang Li
Aug 3, 2017·Journal of Cellular and Molecular Medicine·Yanlei LiTieju Liu
Oct 13, 2017·Biochemical and Biophysical Research Communications·Rassanee BissanumKanyanatt Kanokwiroon
Oct 19, 2017·International Journal of Oncology·Conglin YeBin Zhang
Nov 7, 2017·International Journal of Molecular Sciences·Emily PulfordSonja Klebe
Dec 6, 2017·British Journal of Cancer·Higinio DopesoDiego Arango
Dec 7, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuixian LiXiuzhen Han
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 23, 2018·Nitric Oxide : Biology and Chemistry·Li LinSheng Li
May 12, 2018·FEBS Letters·Shuh Narumiya, Dean Thumkeo
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liangzhen JiangZhanpeng Lu
Nov 28, 2018·Nature Communications·Tong XiangLin Feng
Jan 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Chao ZhouRui Du

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