Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice

Planta medica
Chien-Hui HungChen-Chen Lee

Abstract

Baicalin is the main flavonoid from the roots of an important medicinal plant, Scutellaria baicalensis, which shows a variety biological activities. Psoriasis is a chronic immune-mediated inflammatory disease that affects the skin. The unmet need of psoriasis is that many patients do not respond adequately to available clinical treatment. In this study, we found that baicalin showed inhibited dermal inflammation in a murine model of psoriasis via topical application of imiquimod. After a 5-day topical imiquimod application, baicalin or the control vehicle cream was to applied to the lesions of BALB/c mice for a further 4 days. The erythema, scaling, and thickness of the epidermal layer significantly improved in the baicalin-treated mice. The levels of interleukin-17A, interleukin-22, interleukin-23, and tumor necrosis factor in the skin significantly decreased after baicalin treatment. Baicalin also inhibited imiquimod-induced interleukin-17A production in skin draining lymph node cells. The infiltration of γδ T cells into the skin lesions induced by imiquimod was also suppressed after baicalin treatment. These results suggest that baicalin inhibited skin inflammation through the inhibition of the interleukin-17/interleukin-23 ...Continue Reading

Citations

Feb 13, 2019·Cells·Young Jin JangSanguine Byun
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bing-You YangHai-Xue Kuang
Mar 13, 2021·Frontiers in Medicine·Guan DonglangTang Zongxiang
Mar 16, 2021·Journal of Receptor and Signal Transduction Research·Zhangyong YinJiongwei Pan

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