Baicalin ameliorates oxidative stress and apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-κB and Nrf2/HO-1 signaling pathway during Mycoplasma gallisepticum infection

Poultry Science
Muhammad IshfaqJichang Li

Abstract

Mycoplasma gallisepticum (MG) infection produces a profound inflammatory response in the respiratory tract and evade birds' immune recognition to establish a chronic infection. Previous reports documented that the flavonoid baicalin possess potent anti-inflammatory, and antioxidant activities. However, whether baicalin prevent immune dysfunction is largely unknown. In the present study, the preventive effects of baicalin were determined on oxidative stress generation and apoptosis in the spleen of chickens infected with MG. Histopathological examination showed abnormal morphological changes including cell hyperplasia, lymphocytes depletion, and the red and white pulp of spleen were not clearly visible in the model group. Oxidative stress-related parameters were significantly (P < 0.05) increased in the model group. However, baicalin treatment significantly (P < 0.05) ameliorated oxidative stress and partially alleviated the abnormal morphological changes in the chicken spleen compared to model group. Terminal deoxynucleotidyl transferase-mediated dUTP nick endlabeling assay results, mRNA, and protein expression levels of mitochondrial apoptosis-related genes showed that baicalin significantly attenuated apoptosis. Moreover, bai...Continue Reading

References

Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Sep 1, 1995·Phytochemistry·K IshimaruK Shimomura
May 23, 1998·Veterinary Pathology·S B LockabyS H Kleven
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 30, 2002·The Journal of Biological Chemistry·Laurie M Zipper, R Timothy Mulcahy
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Oct 29, 2008·Oncogene·K W Yip, J C Reed
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yong Pil HwangHye Gwang Jeong
Nov 23, 2010·Journal of Natural Products·Seok-Joo KimSun-Mee Lee
Jan 24, 2012·Journal of Agricultural and Food Chemistry·Wen-Juan LiMing-Yong Xie
Dec 25, 2012·International Immunopharmacology·Eui-Baek ByunJae-Hun Kim
Jan 25, 2013·International Journal of Molecular Sciences·Yanli MengWeiming Wang
Aug 19, 2014·Archives of Oral Biology·Eun-Jin JangJeong-Dan Cha
Feb 24, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Johanna M GostnerDietmar Fuchs
Mar 29, 2016·Neurotoxicology and Teratology·Jian WangJichang Li
Dec 4, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wen-Juan LiMing-Yong Xie
Dec 14, 2016·European Journal of Medicinal Chemistry·Wei-Yi GongJing-Cheng Dong
Dec 13, 2018·Cellular and Molecular Life Sciences : CMLS·Prakash P PraharajSujit Kumar Bhutia

❮ Previous
Next ❯

Citations

Apr 26, 2020·Pathogens·Sergei N BorchseniusNikolai A Barlev
Jun 17, 2020·Avian Pathology : Journal of the W.V.P.A·Yiluo ChengTengfei Zhang
Jul 29, 2020·Frontiers in Cell and Developmental Biology·Jin Zhou, Jie Huang
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinjun YaoWeiqiao Lv
Feb 3, 2021·Antioxidants·Peter F SuraiMichael T Kidd
May 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fangfang HuangLianxiang Luo
Aug 8, 2021·International Journal of Dermatology·Divya Gupta, Tasduq S Abdullah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Y Zhu
European Journal of Drug Metabolism and Pharmacokinetics
Ting HuangChengliang Zhang
© 2021 Meta ULC. All rights reserved