Baicalin-induced vascular response in rat mesenteric artery: role of endothelial nitric oxide

Clinical and Experimental Pharmacology & Physiology
Yu HuangZhen-Yu Chen


1. Baicalin was isolated and purified from the dry roots of Scutellaria baicalensis Georgi (Huangqin; a traditionally used Chinese medicinal herb) and its effect on the contractility of rat isolated mesenteric arteries was investigated and the role of the endothelium was examined. 2. The concentration-dependent contractile response to U46619 was enhanced by 10(-5) mol/L baicalin in endothelium-intact rings, but this effect was abolished in the presence of 10(-4) mol/L N(G)-nitro-L-arginine or in endothelium-denuded rings. 3. Pretreatment of endothelium-intact rings with baicalin (3 x 10(-5) mol/L) markedly attenuated the relaxant response to A23187, thapsigargin and acetylcholine. 4. The present results indicate an important role for endothelial nitric oxide (NO) in the vascular response to baicalin. Baicalin appears to inhibit NO production and release in the endothelium and this mechanism is likely to be responsible for the enhancement of the U46619-induced contraction and for inhibition of endothelial NO-mediated relaxation by baicalin in rat mesenteric artery.


Mar 9, 2013·Bioscience, Biotechnology, and Biochemistry·Ziyang ChenYukihito Kabuyama
Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Kyungjin LeeHo-Young Choi
May 11, 2017·Phytotherapy Research : PTR·Yu-Yao SunChun-Su Yuan
May 18, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kyungjin Lee, Ho-Young Choi
Dec 19, 2016·Frontiers in Pharmacology·Cuiqing Liu, Yu Huang

Related Concepts

Dose-Response Relationship, Drug
Endothelium, Vascular
Mesenteric Arteries
Nitric Oxide
Vascular Constriction (Function)
Vascular Endothelium-Dependent Relaxation
Rats, Holtzman

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.