Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression.

Biochemical Pharmacology
Zhigang XiaoLin Pei

Abstract

Hippocampal neurogenesis is known to be related to depressive symptoms. Increasing evidence indicates that Wnt/β-catenin signaling regulates multiple aspects of adult hippocampal neurogenesis. Baicalin is a major flavonoid compound with multiple pharmacological effects such as anti-inflammatory, anti-apoptotic, and neuroprotective effects. The current study aimed to explore the antidepressant effects of baicalin and its possible molecular mechanisms affecting hippocampal neurogenesis via the regulation of the Wnt/β-catenin signaling pathway. A chronic mild unpredictable stress (CUMS) model of depression was used in the study. The CUMS-induced mice were treated with baicalin (50 and 100 mg/kg) for 21 days, orally, and the fluoxetine was used as positive control drug. The results indicated that baicalin alleviated CUMS-induced depression-like behaviour, and improved the nerve cells' survival of the hippocampal dentate gyrus (DG) in CUMS-induced depression of model mice and increased Ki-67- and doublecortin (DCX)-positive cells to restore CUMS-induced suppression of hippocampal neurogenesis. The related proteins in the Wnt/β-catenin signaling pathway, which declined in the CUMS-induced depression model of mice, were upregulated af...Continue Reading

References

May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Jul 2, 2002·The American Journal of Psychiatry·Thomas FrodlHans-Jürgen Möller
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Oct 7, 2006·Behavioural Brain Research·Yann S MineurWim E Crusio
Aug 30, 2007·Nature Neuroscience·Amar Sahay, Rene Hen
Aug 25, 2009·Nature Neuroscience·Tomoko KuwabaraFred H Gage
Dec 17, 2009·Cellular Signalling·Chan Gao, Ye-Guang Chen
Nov 26, 2010·Journal of Psychiatric Research·Yulia GolubCarsten T Wotjak
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew B WilkinsonEric J Nestler
Dec 30, 2011·Clinical Pharmacology and Therapeutics·B Voleti, R S Duman
Oct 9, 2012·Science·Amelia J Eisch, David Petrik
Dec 25, 2012·Neuroscience and Biobehavioral Reviews·Paul WillnerCatherine Belzung
Feb 5, 2013·Neurochemical Research·Marta B Wisniewska
Jan 21, 2014·Journal of Ethnopharmacology·Guang Yue SuChun Fu Wu
Jun 3, 2014·Neural Plasticity·Eberhard Fuchs, Gabriele Flügge
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·Syed Mohammed Qasim HussainiMi-Hyeon Jang
Apr 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Li CaiTing-ni Wu
Apr 12, 2016·Physiology & Behavior·Ana Laura López-LópezFrancisco Javier Alarcón Aguilar
Aug 16, 2016·The Journal of Pharmacy and Pharmacology·Jie MaShao Jiang Song
Apr 22, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zheng Zachory WeiLing Wei
Jun 18, 2017·Cell and Tissue Research·Runrui ZhangVerdon Taylor
Jun 21, 2017·Biological Psychiatry·Timothy J SchoenfeldHeather A Cameron
Apr 25, 2018·The International Journal of Neuropsychopharmacology·Jiaojie HuiGuangjun Xi
Jun 13, 2018·Brain Sciences·Kandhasamy SowndhararajanSongmun Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.