Baicalin protects human fibroblasts against ultraviolet B-induced cyclobutane pyrimidine dimers formation

Archives of Dermatological Research
Bing Rong ZhouJie Gao

Abstract

Exposure to ultraviolet B (UVB) irradiation is a major risk factor for the development of skin cancer. Therefore, it is important to identify agents that can offer protection against UVB-caused DNA damage. Photocarcinogenesis is caused largely by mutations at the sites of incorrectly repaired DNA photoproducts, of which the most common are the cyclobutane pyrimidine dimers (CPDs). In this study, a DNA damage model of UVB irradiation-induced fibroblasts was established. The immunocytochemical staining, immuno dot blotting and Western blotting were employed in the study. We demonstrated that pre-treatment of fibroblasts with Baicalin dose-dependently reduced the amount of UVB-generated CPDs. Compared with UVB irradiated cells, UVB-induced p53 accumulation was less pronounced in Baicalin-treated cells. Taken together, these results suggest that Baicalin prevent CPDs formation induced by UVB. Baicalin is therefore a promising protective substance against UVB radiation.

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Citations

May 29, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Se Eun HaJong Kun Park
Nov 20, 2012·Journal of Dermatological Science·Ze GuoDan Luo
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shilpi SinghSuaib Luqman
Jan 11, 2020·ACS Applied Materials & Interfaces·Yuchun QiaoXueji Zhang

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