Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Jingyuan XuMinjian Qin

Abstract

Sirtuin 1 (SirT1) and signal transducer and activator of transcription 3 (STAT3) oppositely regulate hepatic gluconeogenic genes and the association remains to be elucidated. Baicalin is a natural flavonoid with beneficial effects on glucose and lipid metabolism. This study aims to investigate the effect of baicalin on hepatic gluconeogenesis with focus on the regulation of fatty acid mobilization and SirT1/STAT3 pathway. In HFD feeding or fasting state, hepatic gluconeogenesis and fatty acid oxidation induced SirT1 expression due to the increased nicotinamide adenine dinucleotide+ (NAD+) contents. Baicalin reduces endogenous glucose production via suppression of hepatic gluconeogenesis and decreased SirT1 induction via reducing NAD+ accumulation in an energy-sensing way. Fasting increased SirT1 protein in STAT3 immunoprecipitation products and less in the liver of baicalin-treated mice, indicating that baicalin blocked the binding of SirT1 to STAT3 and thus preserved STAT3 acetylation. SirT1 knockdown enhanced the protective effect of baicalin on pyruvate-induced STAT3 phosphorylation and acetylation, these results further indicated that the regulation of STAT3 activity by baicalin was dependent on SirT1. Moreover, HFD feeding...Continue Reading

Citations

Nov 15, 2019·Journal of Ovarian Research·Wei WangGuimin Hao
Feb 6, 2020·Pharmacological Reports : PR·Penghua FangZhenwen Zhang
Dec 1, 2018·Eating and Weight Disorders : EWD·Daixiu YuanLiming Zeng
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian ChenXiaogen Tao
Sep 2, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Penghua FangLe Bu
Jan 25, 2020·Medicine and Science in Sports and Exercise·Zeynab NezamdoostAnna Keska
Aug 5, 2020·Life Sciences·Ahmed M SayedAyman M Mahmoud
Jun 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ji-Won NohByung-Cheol Lee

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