Baker's yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk?

The British Journal of Nutrition
Katie C CarpenterBrian K McFarlin

Abstract

Strenuous aerobic exercise is known to weaken the immune system, and while many nutritional supplements have been proposed to boost post-exercise immunity, few are known to be effective. The purpose of the present study was to evaluate whether 10 d of supplementation with a defined source of baker's yeast β-glucan (BG, Wellmune WGP®) could minimise post-exercise immunosuppression. Recreationally active men and women (n 60) completed two 10 d trial conditions using a cross-over design with a 7 d washout period: placebo (rice flour) and baker's yeast BG (250 mg/d of β-1,3/1,6-glucans derived from Saccharomyces cerevisiae) before a bout of cycling (49 ± 6 min) in a hot (38 ± 2°C), humid (45 ± 2 % relative humidity) environment. Blood was collected at baseline (before supplement), pre- (PRE), post- (POST) and 2 h (2H) post-exercise. Total and subset monocyte concentration was measured by four-colour flow cytometry. Plasma cytokine levels and lipopolysaccharide (LPS)-stimulated cytokine production were measured using separate multiplex assays. Total (CD14⁺) and pro-inflammatory monocyte concentrations (CD14⁺/CD16⁺) were significantly greater at POST and 2H (P<0·05) with BG supplementation. BG supplementation boosted LPS-stimulated p...Continue Reading

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Citations

Apr 30, 2014·Nutrition Journal·Heike StierJoerg Gruenwald
Oct 27, 2015·European Journal of Applied Physiology·Danielle E LevittJakob L Vingren
Aug 16, 2016·European Journal of Applied Physiology·Hui-Ying LukJakob L Vingren
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Dec 22, 2016·European Journal of Clinical Nutrition·B K McFarlinA S Venable
Sep 6, 2017·International Journal of Molecular Sciences·Khawaja Muhammad Imran Bashir, Jae-Suk Choi
Sep 18, 2018·Expert Opinion on Biological Therapy·Priscilla de GraaffReno Debets
Jan 6, 2017·Current Protocols in Cytometry·Andrea L HenningBrian K McFarlin
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Apr 8, 2017·European Journal of Applied Physiology·Danielle E LevittJakob L Vingren
Mar 31, 2020·Molecular Nutrition & Food Research·Elena De Marco CastroHelen M Roche
Apr 21, 2021·Food & Function·Marigoula VlassopoulouAdamantini Kyriacou

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