Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway

Parasitology Research
Albrecht F Kiderlen, Ulrike Laube

Abstract

Balamuthia mandrillaris is a free-living ameba and an opportunistic agent of lethal granulomatous amebic encephalitis (GAE) in humans and other mammals. Its supposed routes of infection have been largely assumed from what is known about Acanthamoeba spp. and Naegleria fowleri, other free-living amebae and opportunistic encephalitis agents. However, formal proof for any migratory pathway, from GAE patients or from animal models, has been lacking. Here, immunodeficient mice were infected with B. mandrillaris amebae by intranasal instillation, the most likely natural portal of entry. By means of classical and immunohistology, the amebae are shown to adhere to the nasal epithelium, progress along the olfactory nerves, traverse the cribriform plate of the ethmoid bone, and finally infect the brain. A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae.

Citations

Oct 13, 2006·Parasitology Research·Peter J FinninRobin B Gasser
Nov 18, 2006·Parasitology Research·Albrecht F KiderlenPhiroze S Tata
Dec 17, 2010·Parasitology Research·Priscilla J HodgeSam N Long
Jul 10, 2007·Current Infectious Disease Reports·Maria T Perez, Larry M Bush
Aug 31, 2013·Trends in Parasitology·Jacob Lorenzo-MoralesBasilio Valladares
Oct 12, 2010·Clinical Microbiology Reviews·J L N BarrattD Stark
Dec 6, 2008·BMC Microbiology·Albrecht F KiderlenAstrid Lewin
Mar 12, 2013·Journal of Tropical Medicine·Jesús Serrano-LunaMireya de la Garza
Sep 12, 2013·Parasitology Research·Stephen A LoboMarc Y El Khoury
Jan 23, 2016·Journal of the American Veterinary Medical Association·Jenessa L GjeltemaRyan S De Voe
Dec 2, 2008·Experimental Parasitology·Christian GianinazziBruno Gottstein
Oct 5, 2007·Microbial Pathogenesis·Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Jun 7, 2005·Journal of Neurochemistry·Peter BergmanBirgitta Agerberth
Nov 5, 2014·The Journal of Eukaryotic Microbiology·Albrecht F KiderlenA Julio Martínez
Nov 15, 2013·Virulence·Richard James Thomas
Apr 13, 2007·FEMS Immunology and Medical Microbiology·Govinda S VisvesvaraFrederick L Schuster
Jul 3, 2015·Journal of Clinical Microbiology·Katherine R SchaferGovinda Visvesvara
Oct 23, 2014·Epidemiology and Infection·C D ToddJ Lorenzo-Morales
May 19, 2011·Nature Reviews. Neuroscience·Krister Kristensson
Sep 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer R CopeSharon L Roy
Dec 19, 2006·Journal of Medical Microbiology·Abdul MatinNaveed Ahmed Khan
Mar 12, 2016·Parasitology Research·Carsten Balczun, Patrick L Scheid
Sep 18, 2017·Experimental Parasitology·Maritza Omaña-MolinaJacob Lorenzo-Morales

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