Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density

Journal of Vascular Research
Simone PostAryan Vink

Abstract

Atherosclerotic plaque microvessels are associated with plaque hemorrhage and rupture. The mechanisms underlying plaque angiogenesis are largely unknown. Angiopoietin (Ang)-1 and -2 are ligands of the endothelial receptor Tie-2. Ang-1 induces formation of stable vessels, whereas Ang-2 destabilizes the interaction between endothelial cells and their support cells. We studied the expression patterns of Ang-1 and -2 in relation to plaque microvessels. Carotid endarterectomy specimens were studied (n = 100). Microvessel density (MVD) was correlated with the presence of macrophages and with a (fibro)atheromatous plaque phenotype. A negative correlation was observed between Ang-1 expression and MVD. A positive correlation was observed between the ratio of Ang-2/Ang-1 and MVD. Ang-2 expression was correlated with matrix metalloproteinase-2 (MMP-2) activity. Immunohistochemical staining of Ang-1 was observed in smooth muscle cells, whereas Ang-2 was detected in endothelial cells, smooth muscle cells and macrophages. In plaques with high MVD, the local balance between Ang-1 and Ang-2 is in favor of Ang-2. Plaque Ang-2 levels are associated with MMP-2 activity. Ang-2-induced MMP-2 activity might play a role in the development of (unstabl...Continue Reading

References

Sep 23, 2000·Nature·G D YancopoulosJ Holash
Jul 10, 2001·The British Journal of Surgery·R MofidiT V Keaveny
Dec 13, 2002·Fertility and Sterility·Rosalyn D BlumenthalDavid M Goldenberg
Feb 7, 2003·The New England Journal of Medicine·Lingling DuPatricia A Thistlethwaite
Jul 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bo HuShi-Yuan Cheng
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Jan 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Cristina CalviMaria Felice Brizzi
Apr 20, 2004·Journal of Hepatology·Takuji TorimuraMasamichi Kojiro
Aug 13, 2004·The Journal of Pathology·Catherine R Tait, Pamela F Jones
Feb 3, 2005·Journal of Cell Science·Marion ScharpfeneckerHellmut G Augustin
May 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Fiorentina RoviezzoAndreas Papapetropoulos
Jul 23, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Renu VirmaniJagat Narula
Jul 28, 2005·Cellular Immunology·Neil E HubbardKent L Erickson
Sep 9, 2006·Current Opinion in Lipidology·Karen S Moulton
Oct 19, 2006·Trends in Immunology·Ulrike Fiedler, Hellmut G Augustin

❮ Previous
Next ❯

Citations

Mar 17, 2010·Molecular Biology Reports·Jinfeng WangDonggang Xu
Sep 18, 2013·Biochemical Pharmacology·Tobias HilbertPascal Knuefermann
Mar 15, 2011·European Heart Journal·Jean-Baptiste MichelGerard Pasterkamp
Feb 25, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sascha DavidJan T Kielstein
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Areck A UcuzianHoward P Greisler
Apr 9, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bernard C M te BoekhorstCees J A van Echteld
Oct 12, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ming Kai LamClark J Zeebregts
Apr 11, 2012·International Journal of Vascular Medicine·Laszlo DenesVeronika Jancsik
May 27, 2015·International Journal of Molecular Sciences·Junyan XuGuo-Ping Shi
Feb 5, 2013·Trends in Cardiovascular Medicine·Caroline ChengHenricus J Duckers
Mar 10, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sascha DavidJan T Kielstein
Feb 5, 2010·JACC. Cardiovascular Imaging·Aloke V Finn, Rakesh K Jain
Mar 25, 2009·The Journal of Pathology·Judith C Sluimer, Mat J Daemen
Jul 6, 2010·European Journal of Clinical Investigation·Pieter T BotImo E Hoefer
Mar 5, 2010·Fundamental & Clinical Pharmacology·Shraddha V BhadadaMayur M Patel
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Miklos Z MolnarIstvan Mucsi
Jun 13, 2015·Atherosclerosis·Thomas L TheelenSeppo Ylä-Herttuala
May 22, 2010·The American Journal of Pathology·Peter BoorTammo Ostendorf
May 11, 2013·Microvascular Research·Tadanori MammotoAkiko Mammoto
Mar 31, 2012·Atherosclerosis·Petr NachtigalZbynek Strasky
Sep 14, 2010·Atherosclerosis·Alexandra F Trollope, Jonathan Golledge
Jun 1, 2016·Journal of Thrombosis and Haemostasis : JTH·K RathnakumarM Dixit
Nov 2, 2014·Immune Network·Young-Saeng Jang, In-Hong Choi
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Fan-Chi ChangShuei-Liong Lin
Apr 14, 2019·Journal of Clinical Medicine·Gábor Csányi, Bhupesh Singla
Aug 12, 2017·Annals of Medicine·Dimitry A ChistiakovAlexander N Orekhov
Aug 21, 2019·Journal of Receptor and Signal Transduction Research·Jay Bilimoria, Harprit Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.