Balance between Hyperinflammation and Immunosuppression in Sepsis

Seminars in Respiratory and Critical Care Medicine
Hemang Yadav, Rodrigo Cartin-Ceba

Abstract

Sepsis is a major cause of morbidity and mortality among hospitalized patients and the leading cause of death among patients admitted to intensive care units. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. These pathways are concurrent, starting early in the course of sepsis. Given the high burden of morbidity and mortality associated with sepsis, there is an increasing interest in immunomodulatory therapies targeted at improving outcomes in sepsis. This review will summarize current understanding about the balance between hyperinflammation and immunosuppression in sepsis and discuss the role of potential therapies to modulate these responses.

Citations

Apr 1, 2017·American Journal of Respiratory and Critical Care Medicine·Grant Waterer, Marcos I Restrepo
Mar 21, 2018·Nature Chemical Biology·Anne E ClatworthyDeborah T Hung
Dec 28, 2019·Journal of Cellular and Molecular Medicine·Yun GeYong-Ming Yao
Dec 30, 2017·Experimental and Therapeutic Medicine·Yuxia JiaoJunyu Xiong
Nov 12, 2019·American Journal of Respiratory and Critical Care Medicine·Emely VerweyenChristoph Kessel
Mar 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yun GeMan Huang
Sep 5, 2019·International Journal of Molecular Sciences·Anderson VulczakMaria José Alves Rocha
Jul 1, 2018·Inflammation·Yan ZhaoYurong Kou
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Jan 30, 2020·Acta Pharmaceutica Sinica. B·Chuanzhu Lv, Ling Huang
May 8, 2021·BioMed Research International·Zhaojun LiuErzhen Chen
Jun 3, 2021·Medicina·Salvatore Lucio CutuliGennaro De Pascale

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