Balance in multiple sclerosis: relationship to central brain regions

Experimental Brain Research
Richard L DotyDzung L Pham

Abstract

Dizziness, postural instability, and ataxia are among the most debilitating symptoms of multiple sclerosis (MS), reflecting, in large part, dysfunctional integration of visual, somatosensory, and vestibular sensory cues. However, the role of MS-related supratentorial lesions in producing such symptoms is poorly understood. In this study, motor control test (MCT) and dynamic sensory organization test (SOT) scores of 58 MS patients were compared to those of 72 healthy controls; correlations were determined between the MS scores of 49 patients and lesion volumes within 26 brain regions. Depending upon platform excursion direction and magnitude, MCT latencies, which were longer in MS patients than controls (p < 0.0001), were correlated with lesion volumes in the cortex, medial frontal lobes, temporal lobes, and parietal opercula (r's ranging from 0.20 to 0.39). SOT test scores were also impacted by MS and correlated with lesions in these same brain regions as well as within the superior frontal lobe (r's ranging from - 0.28 to - 0.40). The strongest and most consistent correlations occurred for the most challenging tasks in which incongruent visual and proprioceptive feedback were given. This study demonstrates that supratentorial ...Continue Reading

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Citations

May 6, 2020·Journal of Clinical Medicine·Hernan InojosaTjalf Ziemssen
Feb 29, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·L Eduardo Cofré LizamaMary P Galea
Apr 5, 2021·Multiple Sclerosis and Related Disorders·Clayton W SwansonBrett W Fling
Apr 20, 2021·Journal of Neurologic Physical Therapy : JNPT·Graham D CochraneRobert W Motl

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