Balanced approach of gammadelta T cells to type 2 immunity

Immunology and Cell Biology
Willi K BornRebecca L O'Brien

Abstract

Substantial evidence has been accumulated to indicate that gammadelta T cells take part in type 2 immune responses. It is not yet clear, however, in what capacity. Apparently, gammadelta T cells themselves can not only take the function of follicular T helper (T(H)) cells in certain responses, but also can support responses that are dependent on classical help provided by alphabeta T cells. Furthermore, the gammadelta T cells engage as regulators of T(H2) immunity. Here, we consider two mouse models that depend on type 2 immunity, non-specific airway hyperresponsiveness to methacholine after allergen inhalation challenge and the primary IgE response induced by alum-aided immunization, and examine the function of gammadelta T cells. In either case, gammadelta T cells regulate type 2 immunity through balanced enhancing and inhibitory influences. However, after airway allergen exposure, suppressive gammadelta T cells become dominant. The underlying mechanisms are discussed.

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Citations

Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yafei HuangWilli K Born
Jul 6, 2014·Journal of Immunology Research·Rui Zheng, Qintai Yang
Jun 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nansalmaa AmarsaikhanSteven P Templeton
Feb 3, 2016·American Journal of Reproductive Immunology : AJRI·Han LuLi-Ping Jin
Nov 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yafei HuangWilli K Born
Nov 30, 2019·Clinical Reviews in Allergy & Immunology·Chao HuangZhigang Tian
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Willi K BornRebecca L O'Brien
Jan 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yafei HuangWilli K Born
Mar 22, 2020·Cells·Francesca RampoldiImmo Prinz

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