Balanced placebo design with marijuana: pharmacological and expectancy effects on impulsivity and risk taking.

Psychopharmacology
Jane MetrikDamaris J Rohsenow

Abstract

Marijuana is believed to increase impulsivity and risk taking, but the processes whereby it affects such behaviors are not understood. Indeed, either the pharmacologic effect of delta-9-tetrahydrocannabinol (THC) or the expectancy of receiving it may lead to deficits in cognitive processing and increases in risk taking. We examined the relative effects of expecting to receive active marijuana and the pharmacological drug effects using a balanced placebo design. Young adult regular marijuana users (N = 136) were randomly assigned into one of four groups in a two × two instructional set (Told THC vs. Told no THC) by drug administration (smoked marijuana with 2.8 % THC vs. placebo) design. Dependent measures included subjective intoxication, behavioral impulsivity, and decision-making related to risky behaviors. Active THC, regardless of expectancy, impaired inhibition on the Stop Signal and Stroop Color-Word tasks. Expectancy of having smoked THC, regardless of active drug, decreased impulsive decision-making on a delay discounting task among participants reporting no deception and increased perception of sexual risk among women, consistent with a compensatory effect. Expectancy of smoking THC in combination with active THC incre...Continue Reading

References

Mar 1, 1991·Journal of the Experimental Analysis of Behavior·H RachlinD Cross
May 1, 1989·Psychological Bulletin·L C Crowe, W H George
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·R W FoltinG D Pearlson
Jun 1, 1985·Drug and Alcohol Dependence·L D ChaitC R Schuster
Feb 1, 1995·Drug and Alcohol Dependence·S E LukasR Benedikt
Oct 1, 1994·Journal of Experimental Psychology. Human Perception and Performance·G D Logan
Jun 1, 1996·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·F M CostaJ E Donovan
May 1, 1997·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·L A ShrierR H DuRant
Feb 1, 1997·Experimental and Clinical Psychopharmacology·K FrommeE D'Amico
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·J M KirkH De Wit
Apr 30, 1999·Journal of the Experimental Analysis of Behavior·J B RichardsH de Wit
Feb 22, 2000·Epidemiologic Reviews·M N Bates, T A Blakely
Nov 1, 2001·Archives of General Psychiatry·H G PopeD Yurgelun-Todd
Oct 16, 2001·Journal of the Experimental Analysis of Behavior·J MyersonM Warusawitharana
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C L HartM W Fischman
Jun 22, 2002·Journal of Experimental Psychology. Applied·C W LejuezRichard A Brown
Oct 31, 2002·Human Psychopharmacology·J. G. RamaekersJ. F. O'Hanlon
Mar 14, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Catherine N M OrtnerMary C Olmstead
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer McDonaldHarriet de Wit
Nov 25, 2003·Psychological Research·Guido P H BandMaurits W van der Molen
Dec 4, 2003·Accident; Analysis and Prevention·Olaf H DrummerPhilip Swann
Jan 17, 2004·Drug and Alcohol Dependence·J G RamaekersO H Drummer
Mar 10, 2004·Behavioral and Cognitive Neuroscience Reviews·Mark T Fillmore
May 5, 2004·Experimental and Clinical Psychopharmacology·Kenneth A PerkinsAnthony Caggiula
Sep 24, 2004·Drug and Alcohol Dependence·Christopher T WhitlowLinda J Porrino
Nov 3, 2004·Behavioural Processes·Brady Reynolds, Ryan Schiffbauer
Mar 19, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott D LaneCythia J Pietras
May 24, 2005·NeuroImage·Karen I BollaJean L Cadet
Oct 6, 2005·Journal of Psychopharmacology·E J K WadsworthA P Smith
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Maria TestaLenwood W Hayman
Mar 7, 2006·Pharmacology, Biochemistry, and Behavior·Brady ReynoldsHarriet de Wit
Mar 31, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johannes G RamaekersManfred R Moeller
May 13, 2006·AIDS and Behavior·Jeannette BrodbeckFranz Moggi
Feb 14, 2007·Experimental and Clinical Psychopharmacology·William L Kelemen, Farnaz Kaighobadi
May 15, 2007·Journal of Clinical and Experimental Neuropsychology·Nehal P VadhanRichard W Foltin
Oct 12, 2007·Drug and Alcohol Dependence·Barbara C LeighAlan W Stacy
Aug 23, 2008·Journal of Psychopharmacology·J G RamaekersM R Moeller
Nov 13, 2008·Journal of Experimental Psychology. General·Frederick Verbruggen, Gordon D Logan

❮ Previous
Next ❯

Citations

Jul 19, 2013·Psychological Medicine·Johannes Wrege, Stefan Borgwardt
Jan 10, 2014·Science Translational Medicine·Slavenka Kam-HansenRami Burstein
Oct 23, 2013·Addictive Behaviors·Christopher S Lamb, William D Crano
Nov 13, 2014·The New England Journal of Medicine·Jean-Paul Chretien
Feb 14, 2015·Current Addiction Reports·Jessica WeaferHarriet de Wit
Nov 10, 2013·The American Journal of Drug and Alcohol Abuse·Francesca Filbey, Uma Yezhuvath
Feb 10, 2016·Biological Psychiatry·Samantha J BroydNadia Solowij
May 24, 2015·Drug and Alcohol Dependence·Elizabeth R AstonJames MacKillop
Oct 11, 2013·British Journal of Pharmacology·J H P van WelJ G Ramaekers
Jan 1, 2015·Psychological Inquiry·Arpana Agrawal, Ryan Bogdan
Jan 15, 2013·Drug and Alcohol Dependence·Anne M DayChristopher W Kahler
Jun 12, 2013·Drug and Alcohol Dependence·Ayca Coskunpinar, Melissa A Cyders
May 27, 2016·Scientific Reports·J G RamaekersR J Verkes
Aug 16, 2016·Drug and Alcohol Dependence·Jane MetrikJames MacKillop
Oct 5, 2016·Forensic Science International : Synergy·Percy BondallazChristian Giroud
Apr 16, 2018·Alcoholism, Clinical and Experimental Research·Jane MetrikBrian Borsari
Jul 4, 2018·Alcoholism, Clinical and Experimental Research·Andres L PazJoshua Conniff
Sep 11, 2018·Behavioural Pharmacology·Priscilla P OomenMatthijs G Bossong
Mar 13, 2019·Human Psychopharmacology·Laura M JulianoKathryn C Edwards
Jul 20, 2019·Journal of Psychoactive Drugs·Brianna R AltmanM Earleywine
Jun 12, 2019·The American Journal of Drug and Alcohol Abuse·Rohan H C PalmerJane M Metrik
Aug 1, 2019·The American Journal of Drug and Alcohol Abuse·Alison C BurggrenEdythe D London
Aug 14, 2019·Addiction·Emese KroonJanna Cousijn
Sep 15, 2019·Journal of Dual Diagnosis·Hollis C KarolySarah W Feldstein Ewing
Dec 13, 2019·Journal of Gambling Studies·Ken C Winters, James P Whelan
Sep 28, 2017·Behavioural Pharmacology·Vanessa Minervini, Charles P France
Feb 27, 2020·Behavioural Pharmacology·Vanessa Minervini, Charles P France
Apr 3, 2018·Cannabis and Cannabinoid Research·L Cinnamon BidwellKent E Hutchison
Jun 30, 2019·Psychopharmacology·Lilian KloftJohannes G Ramaekers
Feb 6, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J G RamaekersE L Theunissen
Mar 30, 2017·Behavioural Processes·Justin C StricklandWilliam W Stoops
Aug 22, 2020·Current Opinion in Psychology·Emese KroonJanna Cousijn
Sep 2, 2021·Addiction Biology·Laurel P GibsonKent E Hutchison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.