Balancing exercise risk and benefits: lessons learned from sickle cell trait and sickle cell anemia

Robert I Liem


Development of exercise guidelines for individuals with sickle cell trait (SCT) and sickle cell anemia (SCA) is hampered by the need to weigh the benefits against risks of exercise in these populations. In SCT, concern for exercise collapse associated with sickle cell trait has resulted in controversial screening of student athletes for SCT. In SCA, there exists unsubstantiated concerns that high-intensity exercise may result in pain and other complications. In both, finding the "right dose" of exercise remains a challenge for patients and their providers. Despite assumptions that factors predisposing to adverse events from high-intensity exercise overlap in SCT and SCA, the issues that frame our understanding of exercise-related harms in both are distinct. This review will compare issues that affect the risk-benefit balance of exercise in SCT and SCA through these key questions: (1) What is the evidence that high-intensity exercise is associated with harm? (2) What are the pathophysiologic mechanisms that could predispose to harm? (3) What are the preventive strategies that may reduce risk? and (4) Why do we need to consider the benefits of exercise in this debate? Addressing these knowledge gaps is essential for developing an...Continue Reading


Jan 1, 1975·Scandinavian Journal of Rheumatology·B EkblomG Sätterström
Sep 24, 1987·The New England Journal of Medicine·J A KarkC J Ruehle
Jul 17, 1996·JAMA : the Journal of the American Medical Association·S N BlairL W Gibbons
Apr 8, 1999·Journal of the American College of Cardiology·P ClarksonJ E Deanfield
Feb 22, 2000·International Journal of Sports Medicine·F MattuschR Rost
Mar 4, 2000·The Journal of Pediatrics·J Schneiderman-WalkerJ J Reisman
Sep 27, 2001·Endothelium : Journal of Endothelial Cell Research·Paule BarbeauBernard Gutin
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Leigh A CallahanBernard Gutin
May 6, 2004·The Journal of Pediatrics·Katie WattsDaniel J Green
May 17, 2005·Journal of the American College of Cardiology·Christos Kasapis, Paul D Thompson
Jul 15, 2005·Medicine and Science in Sports and Exercise·Géraldine MonchaninCyril Martin
Mar 1, 2006·European Journal of Applied Physiology·Philippe ConnesOlivier Hue
May 9, 2006·Medicine and Science in Sports and Exercise·Leslee F Sanders, Glen E Duncan
Jun 13, 2006·International Journal of Sports Medicine·Fagnété SaraOlivier Hue
Mar 24, 2007·American Journal of Respiratory and Critical Care Medicine·Anastasia AnthiMark T Gladwin
May 15, 2007·International Journal of Sports Medicine·Laurent MarlinOlivier Hue
Nov 13, 2007·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Julien TripettePhilippe Connes
May 24, 2008·British Journal of Sports Medicine·Julien TripetteMarie-Dominique Hardy-Dessources
Aug 30, 2008·Autonomic Neuroscience : Basic & Clinical·Mona HedrevillePhilippe Connes
Jun 29, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Julien TripettePhilippe Connes
Jun 29, 2010·Medicine and Science in Sports and Exercise·Felipe Augusto Rodrigues MendesCelso Ricardo Fernandes Carvalho
Sep 14, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Juliano Lara FernandesCarlos Eduardo Negrão
May 17, 2011·British Journal of Haematology·Edwige Balayssac-SiransyPascal Bogui
Oct 1, 2011·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Kruti AcharyaLainie F Ross
Dec 7, 2011·American Journal of Preventive Medicine·Lanetta B JordanKwaku Ohene-Frempong
Feb 11, 2012·Journal of Applied Physiology·Erica N ChiricoVincent Pialoux
Jul 20, 2012·Medicine and Science in Sports and Exercise·Francis G O'ConnorPatricia A Deuster
Apr 2, 2013·European Journal of Applied Physiology·Patricia A DeusterYuval Heled
Jul 13, 2013·Sports Medicine·Philipp A EichenbergerChristina M Spengler
May 7, 2014·American Journal of Hematology·Eduard J van BeersPaul Bresser
Jun 26, 2014·Clinical Hemorheology and Microcirculation·Mor DiawPhilippe Connes
Nov 11, 2014·British Journal of Haematology·Emmanuelle CharrinCyril Martin
Dec 30, 2014·Journal of Applied Physiology·Joshua DenhamFadi J Charchar
Feb 24, 2015·The Cochrane Database of Systematic Reviews·Bernard McCarthyYves Lacasse
Mar 11, 2015·Current Sports Medicine Reports·Richard D QuattroneFrancis G O'Connor
Aug 16, 2016·The New England Journal of Medicine·D Alan NelsonLianne M Kurina
Sep 28, 2016·Heart Failure Reviews·Pallav DekaBernice Yates
Jun 10, 2017·Pediatric Blood & Cancer·Robert I LiemAlexis A Thompson
Jun 19, 2017·Blood Cells, Molecules & Diseases·Emmanuelle CharrinCyril Martin
Oct 12, 2017·American Journal of Epidemiology·D Alan NelsonLianne M Kurina
Jan 11, 2018·Cell Metabolism·Martin WhithamMark A Febbraio


Aug 21, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Michele Arigliani, Atul Gupta
Jan 5, 2021·Current Sports Medicine Reports·Francis G O'ConnorPatricia A Deuster
Feb 10, 2021·Current Sports Medicine Reports·David G LiddleAnna L Waterbrook
Oct 10, 2020·Hematology, Transfusion and Cell Therapy·Dayse Mota Rosa PintoJefferson Petto

Related Concepts

Pain, Splitting
Sickle Cell Trait
Exercise, Isometric
Anemia, Sickle Cell
Adverse Event
Population Group
EAF2 gene
Screening Generic

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Hematology Reports
Morey A Blinder, Sarah Russel
Canadian Family Physician Médecin De Famille Canadien
Neil R BellKaylyn L Kretschmer
© 2021 Meta ULC. All rights reserved