Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis

Journal of Immunology Research
Haoshu FangUta Dahmen

Abstract

Sepsis and SIRS (systemic inflammatory response syndrome) belong to a severe disease complex characterized by infection and/or a whole-body inflammatory state. There is a growing body of evidence that neutrophils are actively involved in sepsis and are responsible for both release of cytokines and phagocytosis of pathogens. The neutrophil level is mainly regulated by G-CSF, a cytokine and drug, which is widely used in the septic patient with neutropenia. This review will briefly summarize the role of neutrophils and the therapeutic effect of G-CSF in sepsis. We further suggest that targeting neutrophil function to modulate the balance between innate immunity and inflammatory injury could be a worthwhile therapeutic strategy for sepsis.

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Citations

Sep 1, 2017·Shock·Laure StielJulie Helms
Jun 1, 2018·Journal of Immunology Research·A KovtunA Ignatius
Dec 12, 2019·Inflammation·Haiyan XueFengxue Zhu
Jun 28, 2019·Frontiers in Immunology·Patricia Martinez-QuinonesCamilla Ferreira Wenceslau
Oct 28, 2017·Journal of Immunology Research·Dong-Dong WuXin-Ying Ji
Apr 22, 2021·Acta Biomaterialia·Jefferson O AbariciaRene Olivares-Navarrete
Feb 12, 2021·American Journal of Respiratory Cell and Molecular Biology·Paulette A KrishackPhilip A Verhoef
Apr 14, 2021·Antioxidants & Redox Signaling·Kiyoshi ItagakiCarl J Hauser
Jun 4, 2021·Pulmonary Pharmacology & Therapeutics·Carmen Lorena Robaina CabreraClive Page

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