Balancing neuronal death

Journal of Neuroscience Research
Giselle F Prunell, Carol M Troy

Abstract

Although it is apparent that neuronal death must be tightly regulated to ensure the proper development and mature functions of the nervous system, the molecular details of this regulation are not fully understood. In multiple neurodegenerative diseases, there is inappropriate death of cells in the nervous system. A better understanding of how death is regulated in the normal nervous system can provide a framework for determining how this regulation can go awry during neurodegenerative disease. The key executioners of neuronal apoptosis, the caspases, are regulated at several levels. The endogenous inhibitor of apoptosis family of proteins, the IAPs, can suppress caspase activity. In this Mini-Review, we examine what is known about the function of IAPs in normal neuronal function and in disease.

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Citations

Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Gabrio BassottiBruno Salerni
Jul 29, 2005·Nature Reviews. Neuroscience·Mylvaganam JeyakumarFrances M Platt
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Feb 13, 2007·Neurobiology of Disease·Lori-Ann ChristieCarl W Cotman
Nov 9, 2010·Neurobiology of Disease·Gauthami S KondagariRosanne M Taylor

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