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Balancing selection is the main force shaping the evolution of innate immunity genes

The Journal of Immunology : Official Journal of the American Association of Immunologists

Jul 9, 2008

Anna Ferrer-AdmetllaFerran Casals

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Abstract

The evolutionarily recent geographic expansion of humans, and the even more recent development of large, relatively dense human settlements, has exposed our species to new pathogenic environments. Potentially lethal pathogens are likely to have exerted important selective pressures on o...read more

Mentioned in this Paper

Genetic Drift
Immune Response
Immune System
Exertion
TLR4 gene
Systemic Inflammatory Response Syndrome
DC-specific ICAM-3 grabbing nonintegrin
TLR10 gene
Genome
Pathogenic Organism
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Balancing selection is the main force shaping the evolution of innate immunity genes

The Journal of Immunology : Official Journal of the American Association of Immunologists

Jul 9, 2008

Anna Ferrer-AdmetllaFerran Casals

PMID: 18606686

DOI: 10.4049/jimmunol.181.2.1315

Abstract

The evolutionarily recent geographic expansion of humans, and the even more recent development of large, relatively dense human settlements, has exposed our species to new pathogenic environments. Potentially lethal pathogens are likely to have exerted important selective pressures on o...read more

Mentioned in this Paper

Genetic Drift
Immune Response
Immune System
Exertion
TLR4 gene
Systemic Inflammatory Response Syndrome
DC-specific ICAM-3 grabbing nonintegrin
TLR10 gene
Genome
Pathogenic Organism

Feeds With Similar Papers

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Human Immune Variation: Genetics, Gender & Time

Establishing the normal range of phenotypic variation within and between individuals requires consideration of contributions from genetics and the environment. Find the latest research on variations in the human immune system here.

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