PMID: 11923112Mar 30, 2002Paper

Balancing susceptibility to infection and autoimmunity: a role for leptin?

Trends in Immunology
Giuseppe MatareseSerafino Zappacosta

Abstract

The immune responses to many infections have long been known to share features with autoimmune responses. In particular, both types of response are typified by the enhanced reactivity of T helper 1 cells - with high levels of interleukin-2, interferon gamma and tumor necrosis factor alpha - and are accompanied often by organ-specific and/or systemic damage and the production of IgG. Paradoxically, the geographical distributions of incidence of infectious diseases and autoimmunity are complementary, rather than coincident. In less-developed societies, an epidemiological association between susceptibility to infection and malnutrition has been observed, whereas in affluent countries, an increased incidence of autoimmune diseases has been described. We suggest that these observations can be explained partly by taking into consideration the immune effects of the adipocyte-derived hormone leptin, which has been shown recently to act as a link between nutritional status and the immune response.

References

Aug 1, 1994·Clinical Immunology and Immunopathology·G Fernandes
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ChanB R Bloom
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z M DongD D Wagner
Dec 31, 1997·Obesity Research·N V DhurandharR L Atkinson
Feb 12, 1998·The Journal of Clinical Investigation·T G KirchgessnerG S Hotamisligil
Jan 4, 1998·Journal of Internal Medicine·T CederholmJ Palmblad
Jun 17, 1998·Journal of the American College of Nutrition·C S MantzorosG J Brewer
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly
Oct 19, 1999·The Journal of Clinical Investigation·J K HowardS R Bloom
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·R FaggioniG Fantuzzi
Jul 20, 2001·Trends in Immunology·P Black
Oct 5, 2001·Cellular Signalling·G Frühbeck, J Gómez-Ambrosi
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
Jan 7, 2011·Biology of Sex Differences·Rhonda Voskuhl

❮ Previous
Next ❯

Citations

Jun 21, 2006·Archives of Dermatological Research·Nilsel OkudanFatih Sari
Jul 19, 2008·Molecular Biotechnology·Huitong ZhouHua Gong
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Mar 25, 2004·Trends in Immunology·Giuseppe Matarese, Antonio La Cava
Jun 11, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Caroline M Pond
Jul 13, 2007·The Journal of Laryngology and Otology·M GuvenH Erdoğan
Jul 8, 2010·Nature Reviews. Neurology·Giuseppe MatareseAntonio La Cava
Apr 21, 2007·Pancreas·Krystian AdrychJulian Swierczynski
Nov 21, 2009·Journal of Applied Physiology·Akshay Sood
Jan 18, 2003·The Journal of Clinical Investigation·Veronica SannaGiuseppe Matarese
Sep 27, 2013·Multidisciplinary Respiratory Medicine·Nazan CobanogluNerin Nadir Bahceciler
May 3, 2007·PLoS Medicine·Ulrich E Schaible, Stefan H E Kaufmann
Jun 10, 2011·International Journal of Environmental Research and Public Health·Alice BonanniGiacomo Garibotto
May 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean L ChanChristos S Mantzoros
Jun 27, 2014·International Immunology·Oscar Ramirez, Kristine M Garza
Jun 12, 2003·Journal of Neuroimmunology·Anna Paola BatocchiMassimiliano Mirabella
Jul 4, 2012·Biochimie·Fortunata CarboneGiuseppe Matarese
Nov 2, 2011·Molecular Aspects of Medicine·Claudio ProcacciniGiuseppe Matarese
May 25, 2010·Trends in Molecular Medicine·Giuseppe MatareseAntonio La Cava
Jun 6, 2009·Journal of Neuroimmunology·Sandra Columba-CabezasFrancesca Cirulli
May 7, 2010·The Journal of Investigative Dermatology·Batya B DavidoviciJames G Krueger
Sep 22, 2007·Metabolism: Clinical and Experimental·Eric ToussirotDaniel Wendling
Jun 26, 2007·The Journal of Allergy and Clinical Immunology·Xiao-Mei MaiAnita L Kozyrskyj
May 23, 2015·Life Sciences·Lennart ZabeauJan Tavernier
May 21, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Xiao-Mei MaiDaniel Krewski
Mar 2, 2006·European Journal of Clinical Investigation·S N WangK T Lee
May 9, 2008·Journal of Neuroendocrinology·N BattistaM Maccarrone
Aug 15, 2012·Immunological Reviews·Giuseppe MatareseVeronica De Rosa
Nov 19, 2011·Scandinavian Journal of Medicine & Science in Sports·C BerneckerM Halle
Aug 6, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jonathan C K Wells, Mario Cortina-Borja
May 3, 2006·Experimental Cell Research·S Caspar-BauguilL Pénicaud
Dec 29, 2005·Journal of Autoimmunity·Lisa K GilliamCatherine Pihoker
Jun 26, 2003·Clinical and Experimental Immunology·V Sánchez-MargaletC Gonzalez-Yanes
Oct 16, 2004·Obesity Research·Antonio Cabrera de LeónIrma Carballo Trujillo
Apr 3, 2004·European Journal of Haematology·Mei ZhanZhong Chao Han
Jan 17, 2004·Clinical Endocrinology·G MazziottiJ H Lazarus
Dec 22, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Xiao-Mei MaiIngemar Leijon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.