PMID: 6159483Nov 1, 1980Paper

BALB/c myeloma retroviruses: peptide mapping and immunological analysis of the pp12 structural protein

Journal of Virology
D R Spriggs, R G Krueger

Abstract

We have compared the pp12 structural protein of the MO-21 and FL-1 BALB/c myeloma retroviruses with the pp12 of several prototype retroviruses. Chymotryptic peptide maps of 125I-labeled, immune-precipitated pp12 proteins revealed that the MO-21 and FL-1 proteins can be distinguished from one another. The MO-21 pp12 most closely resembled the NIH-xenotrophic virus pp12, and the FL-1 pp12 most closely resembled the pp12 of BV-2 and WN 1802 B. Competition radioimmunoassay studies showed that the MO-21 and FL-1 pp12 proteins are also antigenically distinct from one another and that both contain pp12 antigenic determinants of a xenotropic virus. These data support our proposal that these two BALB/c viruses contain a gag gene that was generated by recombination between endogenous eco- and xenotropic viral sequences.

References

Oct 1, 1979·Journal of Virology·J P BrownR C Nowinski
Mar 1, 1975·Journal of Virology·B K Pal, P Roy-Burman
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·S A Aaronson, J R Stephenson
Sep 1, 1977·The Journal of General Virology·E G HaymanP Roy-Burman
Mar 30, 1978·Biochemical and Biophysical Research Communications·B K Pal, P Roy-Burman
Nov 21, 1977·Biochemical and Biophysical Research Communications·A SenG J Todaro
Feb 1, 1974·The Journal of Experimental Medicine·J R StephensonS A Aaronson
Dec 1, 1972·The Journal of Allergy and Clinical Immunology·J W Yunginger, G J Gleich
Nov 1, 1980·Journal of Virology·D R SpriggsR G Krueger
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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