Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease

PloS One
Magdalena A T BrunnerMonika M Welle

Abstract

Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only endocrinopathies have been ruled out scientifically. The overall goal of our study was to identify the cause of bald thigh syndrome and the pathological changes associated with it. We approached this aim by comparing skin biopsies and hair shafts of affected and control dogs microscopically as well as by applying high-throughput technologies such as genomics, transcriptomics and proteomics. While the histology is rather unspecific in most cases, trichogram analysis and scanning electron microscopy revealed severe structural abnormalities in hair shafts of affected dogs. This finding is supported by the results of the transcriptomic and proteomic profiling where genes and proteins important for differentiation of the inner root sheath and the assembly of a proper hair shaft were downregulated. Transcriptome profiling revealed a downregulation of genes encoding 23 hair shaft keratins and 51 keratin associated proteins, as well as desmosomal cadherins and several actors of the BMP signaling pathway which is important for...Continue Reading

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Datasets Mentioned

BETA
PRJEB21761
PXD012371
PRJEB16012

Methods Mentioned

BETA
biopsies
scanning electron microscopy
sedation
biopsy
RNA-seq
HTseq
proteomic profiling
skin

Software Mentioned

Andromeda
SnpEFF
DESeq2
HTseq
R
MaxQuant
samtools
GATK
STAR aligner
picard

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