Balloon angioplasty plus cilostazol administration versus primary stenting of small coronary artery disease: final results of COMPASS

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
E TsuchikaneTohru Kobayashi

Abstract

Efficacy of primary stenting in small coronary artery disease is still controversial. Cilostazol has been reported to control restenosis after balloon angioplasty (BA). The aim was to compare primary stenting with BA plus cilostazol administration in small coronary artery disease. Of 106 lesions located in small coronary artery (reference < 3.0 mm), 50 lesions were randomly assigned to the stenting and 56 lesions to the BA-cilostazol group. Multilink stent was implanted in the stenting group. In the BA-cilostazol group, cilostazol (200 mg/day) without aspirin was administered for 6 months after BA. Ticlopidine was given for 1 month when bailout stent was implanted. Serial quantitative angiography was performed at the procedure and 6 months. The primary endpoint was 6-month angiographic restenosis. Clinical event rates at 1 year were also assessed. Baseline characteristics were similar. All procedures were successful. Bailout stenting was performed in three lesions in the BA-cilostazol group. No side effects of cilostazol were observed. Postprocedural lumen diameter was significantly larger (2.69 vs. 2.03 mm; P < 0.0001) in the stenting group. However, the follow-up lumen diameter was not different (1.76 vs. 1.85 mm, stenting vs...Continue Reading

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Citations

Aug 6, 2013·Cardiovascular Therapeutics·Muslum SahinMehmet M Turkmen
Sep 20, 2005·American Heart Journal·Yaling HanJunbo Ge
Jun 20, 2016·JACC. Cardiovascular Interventions·George C M SiontisStephan Windecker
Sep 11, 2010·Expert Review of Cardiovascular Therapy·Hiroki Ito, James B Hermiller
Jun 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jorge Sanz SánchezGiuseppe Ferrante

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