Balloon-Assisted Embolization of Wide-Neck Aneurysms Using a Mixture of n-Butyl Cyanoacrylate, Lipiodol, and Ethanol in Swine: A Comparison of Four n-Butyl Cyanoacrylate Concentrations.

Cardiovascular and Interventional Radiology
Mizuki HamaMotoki Nakai

Abstract

To determine the optimal ratio of n-butyl cyanoacrylate (NBCA)-Lipiodol-ethanol (NLE) mixture for balloon-assisted embolization of wide-neck aneurysms. We created 32 wide-neck aneurysms on both the common carotid arteries and external iliac arteries in eight female swine. Eight aneurysms were randomly assigned to four groups. Under balloon occlusion, the aneurysms were packed using NLE at one of four ratios of NLE: 2:2:1 (NLE221; 40%NBCA); 3:6:1 (NLE361; 30%NBCA); 2:7:1 (NLE271; 20%NBCA); and 1:5:1 (NLE151; 14.3%NBCA). We performed angiography before and after embolization to assess the aneurysms, and we compared adhesion between NLE and the balloon and assessed NLE migration. Three days after embolization, the aneurysms were removed for histopathologic evaluation. Embolization was performed in 27 aneurysms. Adhesion between NLE and the balloon was not observed in any group. NLE migration was found in 0/7 aneurysms in the NLE221 group, 0/6 in the NLE361 group, 5/6 in the NLE271 group, and 7/8 in the NLE151 group. NLE migration was significantly lower in the NLE221 group than in the NLE271 and NLE151 groups (P = 0.0047 and 0.0014, respectively) and was significantly lower in the NLE361 group than in the NLE271 and NLE151 groups ...Continue Reading

References

Mar 1, 1987·Journal of Korean Medical Science·J H ParkC W Lee
Jan 1, 1982·Cardiovascular and Interventional Radiology·F StoessleinP A Romaniuk
Jul 3, 2004·Journal of Vascular and Interventional Radiology : JVIR·John William KishSue E Hanks
Apr 30, 2010·Cardiovascular and Interventional Radiology·Akira IkomaIchiro Mori
Oct 30, 2012·Journal of Vascular and Interventional Radiology : JVIR·Nobuyuki KawaiTetsuo Sonomura
Aug 28, 2018·Journal of Vascular and Interventional Radiology : JVIR·Motoki NakaiTetsuo Sonomura
Dec 14, 2018·Cardiovascular and Interventional Radiology·Shunsuke SugawaraYoshitaka Inaba

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Citations

Nov 25, 2020·Cardiovascular and Interventional Radiology·Nobuyuki HigashinoNobuyuki Kawai
May 23, 2021·Cardiovascular and Interventional Radiology·Romaric LoffroyOlivier Chevallier

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