BAlloon versus Stenting in severe Ischaemia of the Leg-3 (BASIL-3): study protocol for a randomised controlled trial

Trials
Benjamin D HuntBASIL-3 Collaborative Group

Abstract

Severe limb ischaemia (SLI) is defined as the presence of rest pain and/or tissue loss secondary to lower extremity atherosclerotic peripheral arterial disease. The superficial femoral and popliteal arteries are the most commonly diseased vessels in such patients and are being increasingly treated using endovascular revascularisation techniques. However, it is currently unknown whether drug-eluting stents and drug-coated balloons confer additional clinical benefits over more established techniques using plain balloons and bare metal stents, or whether they represent a cost-effective use of NHS resources. The BASIL-3 trial is a UK National Institute for Health Research, Health Technology Assessment Programme-funded, multicentre, randomised controlled trial (RCT) comparing the clinical and cost-effectiveness of plain balloon angioplasty with or without bail-out bare metal stenting, drug-coated balloon angioplasty with or without bail-out bare metal stenting, and primary stenting with drug-eluting stents for SLI secondary to femoro-popliteal disease. Patients with 'multilevel' disease may receive aorto-iliac and/or infrapopliteal treatments concurrently with their randomised femoro-popliteal intervention. The primary clinical outc...Continue Reading

References

Aug 1, 1990·Research in Nursing & Health·M E Wewers, N K Lowe
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Dec 8, 1996·Journal of Health Services Research & Policy·C Jenkinson, R Layte
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Jun 22, 2007·Vascular Health and Risk Management·Nicolas W Shammas
Feb 2, 2010·Journal of Vascular Surgery·Vinit N VaruMelina R Kibbe
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A KarthikesalingamR J Hinchliffe
Apr 12, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M HerdmanX Badia
Aug 31, 2011·Applied Health Economics and Health Policy·Terry N FlynnTim J Peters
Oct 16, 2013·Journal of Vascular Surgery·Joseph L MillsUNKNOWN Society for Vascular Surgery Lower Extremity Guidelines Committee
Mar 29, 2014·TheScientificWorldJournal·Georgios PastromasStavros Spiliopoulos
Dec 2, 2014·Seminars in Interventional Radiology·Athanasios Diamantopoulos, Konstantinos Katsanos
Sep 24, 2015·Journal of Vascular Surgery·Abd Moain Abu DabrhMohammad Hassan Murad
Dec 6, 2016·International Journal of Environmental Research and Public Health·David C SchwebelJoan Severson

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Citations

Jul 12, 2018·The New England Journal of Medicine·Alik Farber
Apr 2, 2019·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Michel M P J ReijnenSuzanne Holewijn
Dec 7, 2019·The British Journal of Surgery·G K AmblerC P Twine
Sep 9, 2019·Current Cardiology Reports·Mohamed M GadAhmed N Mahmoud
Apr 22, 2018·Nature Reviews. Cardiology·Jade S HiramotoMichael S Conte
May 15, 2018·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Linda TangRamon L Varcoe
Sep 29, 2019·The Journal of Cardiovascular Surgery·Cornelis G Vos, Jean Paul P M de Vries
Dec 2, 2020·The Cochrane Database of Systematic Reviews·Hidde JongsmaBram Fioole
Dec 18, 2020·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·A V Svetlikov, L É Ishpulaeva
Nov 3, 2020·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Gautam M AnandGary Giangola
Dec 19, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Thea KreutzburgChristian-Alexander Behrendt
Dec 19, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Petar ZlatanovicLazar Davidovic
Jun 5, 2019·Journal of Vascular Surgery·Michael S ConteUNKNOWN GVG Writing Group
May 28, 2021·Journal of Atherosclerosis and Thrombosis·Akio KodamaUNKNOWN SPINACH investigators.
Jun 11, 2021·Circulation Research·Joshua A BeckmanMichael S Conte
Jul 20, 2021·VASA. Zeitschrift für Gefässkrankheiten·Artur KotovChristian-Alexander Behrendt
May 7, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Athanasios SaratzisHany Zayed
Aug 12, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Akio KodamaAndrew W Bradbury

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Methods Mentioned

BETA
amputation
amputations

Software Mentioned

ICEpop
BASIL

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