BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR‑204

International Journal of Oncology
Bingjie CaiFangxia Guan

Abstract

BRAF-activated non-coding RNA (BANCR) is a long non-coding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including melanoma. However, the BANCR functions and downstream mechanisms are largely unknown. In this study, we aim to investigate how BANCR participates in the proliferation and migration of malignant melanoma and elucidate the underlying mechanism in this process. We found that the expression of the BANCR was low in melanocytic nevus and human melanocytes but high in melanoma tissues and cell lines. Knockdown of BANCR inhibited melanoma cell proliferation and invasion, and induced cell apoptosis. The decreased expression of relative marker proteins further demonstrated the inhibitory effect of BANCR siRNA in cell growth and migration. Then, we detected downregulation of microRNA-204 (miR‑204), a suppressor of melanoma growth, in melanoma tissues and cell lines. We identified that miR‑204 was a direct target of BANCR and neurogenic locus notch homolog protein 2 (Notch2) was a direct target of miR‑204. BANCR may promote melanoma cell growth through inhibition of miR‑204, leading to the activation of Notch2 pathway. By tumorigenicity assay in BALB/c nude mice, we further demonstrated ...Continue Reading

References

Mar 18, 2005·Annual Review of Immunology·Ivan MaillardWarren S Pear
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniela MassiMarco Santucci
Feb 23, 2007·Nature·Vanessa Gray-SchopferRichard Marais
Jul 28, 2009·Annual Review of Medicine·Ramiro GarzonCarlo M Croce
May 6, 2010·Cancer Research·Demetra PhilippidouStephanie Kreis
May 12, 2011·Cancer Research·Divya KhaitanRanjan J Perera
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura AsnaghiCharles G Eberhart
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Jun 25, 2013·Cancer Letters·Xuefei ShiYong Song
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming SunXianghua Liu
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Jan 1, 2014·European Urology·Elena S Martens-UzunovaGeorge A Calin
Apr 2, 2014·Mayo Clinic Proceedings·Andrzej T Slominski, J Andrew Carlson
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuan YinZhaohui Huang
Nov 18, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xianyi CaiXianzhe Liu
Nov 28, 2015·Primary Care·Miguel A LinaresParminder Nizran
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 24, 2016·Cell Reports·Karyn SchmidtCarl D Novina
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tianqi LiRunsheng Li
Oct 21, 2016·Pigment Cell & Melanoma Research·Eleonora LeucciKeith W Vance
Nov 30, 2016·Methods in Molecular Biology·Martin A Smith, John S Mattick
Nov 30, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Danni WangXuemei Ren
Feb 28, 2017·Life Sciences·Swarnendra SinghImrana Naseem

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Citations

Dec 7, 2018·Expert Opinion on Therapeutic Targets·Luigi FattoreGennaro Ciliberto
Jan 29, 2021·International Journal of Molecular Sciences·Vincenzo De FalcoTeresa Troiani
Jun 4, 2021·Molecular Oncology·Barbara MonticoElisabetta Fratta
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
Oct 24, 2020·Experimental and Molecular Pathology·Amin SafaSoudeh Ghafouri-Fard
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lijun YangFucheng He

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