Banxia xiexin decoction protects against dextran sulfate sodium-induced chronic ulcerative colitis in mice

Journal of Ethnopharmacology
Gang ChenPeng Cao

Abstract

Banxia Xiexin decoction (BXD), one of a traditional Chinese medicine chronicled in Shang Han Lun, is commonly used to treat gastroenteritis, ulcerative colitis and diarrhea. In our study, we used current biomedical approaches to investigate the therapeutic efficacy of BXD and possible protective mechanism involved in inhibiting dextran sulfate sodium (DSS)-induced chronic ulcerative colitis model. Chronic DSS colitis was induced in C57BL/6 male mice by three cycles of 5 days of 2% DSS in drinking water, alternating with 5 days of normal water, totaling 30 days. In BXD group, the mice were administered at a dose of 8.7g/kg BXD for 5 days before and during DSS treatment via oral gavage per day. Mice in vehicle group and DSS group were given orally the same volume of drinking water, instead. Body weight, stool characters and hematochezia were observed everyday. The colorectal tissues were used to detect levels of TNF-α, IL-4, IL-10, IL-1β, IL-17, IL-23 and MPO by ELISA or qRT-PCR. The expression of COX-2, 8-Oxoguanine and Nrf2 were examined by IHC, and p-p65 was examined by western blotting. ThOD and the content of MDA were measured according to kits respectively. BXD significantly protected against DSS-induced chronic ulcerative ...Continue Reading

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Citations

Sep 1, 2016·Scientific Reports·Juan YePeng Cao
Jan 29, 2020·Journal of Cellular and Molecular Medicine·Wei HeDongdong Sun
Jul 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chunyan WangLi Zhang
Nov 10, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Ming YangXinhong Wang
May 18, 2020·Chinese Journal of Integrative Medicine·Bin WangZhen Liu
Apr 16, 2019·Frontiers in Pharmacology·Liu TangHong Ding
May 17, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zongqi HeYugen Chen
Nov 9, 2020·Natural Products and Bioprospecting·Christian Bailly
Oct 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta PiotrowskaAleksandra Piechota-Polanczyk
Oct 17, 2020·Mediators of Inflammation·Li JiaAhmed E Abdel Moneim
Oct 31, 2020·Current Medical Science·Juan LiGuang Du
Dec 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xueqing Zhong, Hailin Liu

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