PMID: 9528852Apr 7, 1998Paper

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Oncogene
D E JensenF J Rauscher

Abstract

We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized, ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function. BAP1 binds to the wild-type BRCA1-RING finger, but not to germline mutants of the BRCA1-RING finger found in breast cancer kindreds. BAP1 and BRCA1 are temporally and spatially co-expressed during murine breast development and remodeling, and show overlapping patterns of subnuclear distribution. BAP1 resides on human chromosome 3p21.3; intragenic homozygous rearrangements and deletions of BAP1 have been found in lung carcinoma cell lines. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and is the first nuclear-localized ubiquitin carboxy-terminal hydrolase to be identified. BAP1 may be a new tumor suppressor gene which functions in the BRCA1 growth control pathway.

Citations

Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·K YoshikawaR Takahashi
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Sep 21, 2002·Microscopy Research and Technique·Dianne C Daniel
Dec 22, 1999·Biochemical and Biophysical Research Communications·C H Chung, S H Baek
Jun 29, 2000·Biochemical and Biophysical Research Communications·T LiT S Teo
Mar 14, 2002·Biochemical and Biophysical Research Communications·Marijke J van BarenPeter Heutink
May 12, 2001·Pathology Oncology Research : POR·E ForgacsJ D Minna
Nov 26, 2009·Diseases of the Colon and Rectum·Toshiaki WatanabeHirokazu Nagawa
Jan 13, 2012·International Journal of Clinical Oncology·Tohru TsujimuraTakashi Nakano
Dec 13, 2005·Familial Cancer·Isabelle CoupierDominique Stoppa-Lyonnet
Apr 13, 2011·Cell Biochemistry and Biophysics·Ziad M Eletr, Keith D Wilkinson
Mar 26, 2013·Medical Oncology·Jianjun TangTiebang Kang
Jan 23, 2013·Molecular Neurobiology·Laura CampelloJosé Martín-Nieto
Sep 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Rajesh C RaoShiming Chen
Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Feb 25, 2000·Cancer Genetics and Cytogenetics·H TworekR A DiCioccio
Feb 1, 2000·Trends in Genetics : TIG·P L WelcshM C King
Mar 20, 2002·Biochimie·Ralph Scully, Nadine Puget
Dec 26, 2001·Experimental Hematology·S FagerlieG C Bagby
Jul 20, 1999·Molecular and Cellular Endocrinology·W M BaarendsJ A Grootegoed
Dec 2, 1999·Molecular and Cellular Endocrinology·M Schuyer, E M Berns
Sep 18, 1998·Biochimica Et Biophysica Acta·Y SekidoJ D Minna
Jan 16, 2002·Current Opinion in Genetics & Development·Richard Baer, Thomas Ludwig
Jul 20, 2001·The International Journal of Biochemistry & Cell Biology·F Di DonatoJ P Buyon
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Simon S Wing
Dec 6, 2001·Trends in Molecular Medicine·M Futaki, J M Liu
Jan 17, 2009·Chemical Reviews·Katherine WickliffeMichael Rape
Feb 27, 2009·Chemical Reviews·Francisca E Reyes-Turcu, Keith D Wilkinson
Jun 16, 1999·Breast Cancer Research and Treatment·X Yang, M E Lippman
May 21, 2003·Breast Cancer Research and Treatment·Peter O'Connell
Dec 12, 2012·Eye·S E CouplandB E Damato
May 4, 2010·Nature·Johanna C ScheuermannJürg Müller
Aug 15, 2006·Nature Cell Biology·Tingting YaoRobert E Cohen
Jun 12, 2012·Nature Genetics·Samuel Peña-LlopisJames Brugarolas
Aug 30, 2011·Nature Genetics·Thomas WiesnerMichael R Speicher
Aug 30, 2011·Nature Genetics·Joseph R TestaMichele Carbone
Oct 1, 2011·Nature Genetics·Alisa M Goldstein

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