BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Molecular & Cellular Oncology
Yilei ZhangBoyi Gan

Abstract

The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.

References

Apr 1, 2008·Molecular Cell·Vikki M Weake, Jerry L Workman
May 4, 2010·Nature·Johanna C ScheuermannJürg Müller
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 4, 2013·Nature Reviews. Cancer·Michele CarboneGiovanni Gaudino
Mar 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Fangyan DaiBoyi Gan
Sep 12, 2018·Nature Cell Biology·Yilei ZhangBoyi Gan

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Citations

Feb 23, 2020·Genes & Development·Divya VenkateshBrent R Stockwell
Feb 8, 2020·Nature Cell Biology·Hyemin LeeBoyi Gan
Jun 14, 2020·Japanese Journal of Clinical Oncology·Guoping JiangShusen Zheng
Apr 24, 2021·Protein & Cell·Guang LeiBoyi Gan
Apr 11, 2020·Cell Chemical Biology·Annadurai AnandhanDonna D Zhang
Jun 15, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Guang LeiBoyi Gan
Oct 6, 2021·The Journal of Clinical Investigation·Wenjing ZhangYang Wang
Nov 13, 2021·Experimental and Therapeutic Medicine·Weifeng TangYing Wei

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Methods Mentioned

BETA
two-hybrid
xenograft
immunoprecipitation
RNA-seq
deubiquitination
electron

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