BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression

Cell Death & Disease
Erle DangKun Yang

Abstract

Malignant tumors typically undergo an atavistic regression characterized by the overexpression of embryonic genes and proto-oncogenes, including a variety of cancer/testis antigens (CTAs) that are testis-derived and are not expressed or expressed in trace amounts in somatic tissues. Based on this theory, we established a new method to identify unknown CTAs, the spermatogenic cells-specific monoclonal antibody-defined cancer/testis antigen (SADA) method. Using the SADA method, we identified BAP31 as a novel CTA and confirmed that BAP31 expression is associated with progression and metastasis of several cancers, particularly in cervical cancer. We found that BAP31 was significantly upregulated in stage I, II, and III cervical cancer patients and highly correlated with poor clinic outcomes. We further demonstrated that BAP31 regulates cervical cancer cell proliferation by arresting the cell cycle at the G0/G1 stage and that depletion of BAP31 inhibits hyper-proliferation. Moreover, depletion of BAP31 inhibits cervical cancer cell invasion and migration by regulating the expression and subcellular localization of Drebrin, M-RIP, SPECC1L, and Nexilin, and then affect the cytoskeleton assemblage. Finally, the depletion of BAP31 preve...Continue Reading

References

Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·U SahinM Pfreundschuh
Feb 12, 1998·The Journal of Cell Biology·W G AnnaertR Jahn
Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·B LethéT Boon
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Nicole J W de WitGoos N P van Muijen
Nov 26, 2002·Immunological Reviews·Matthew J ScanlanYao-Tseng Chen
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Eve PaquetDavid B Williams
Apr 13, 2005·Biochemical and Biophysical Research Communications·Wei WangRutai Hui
Dec 8, 2005·The Journal of Biological Chemistry·Elzbieta Szczesna-Skorupa, Byron Kemper
Aug 8, 2008·Journal of Virology·Jennifer A Regan, Laimonis A Laimins
Oct 23, 2012·International Reviews of Immunology·Maurizio Chiriva-InternatiRead Alalawi
Dec 4, 2012·Experimental Cell Research·Yuzo TerakawaJames T Rutka
Feb 14, 2013·British Journal of Cancer·S FujiwaraY Doki
Dec 17, 2014·Current Pharmaceutical Design·Ping YangQuansheng Zhou
Apr 23, 2015·International Reviews of Immunology·F GrizziM Chiriva-Internati
Apr 24, 2015·Journal of Experimental & Clinical Cancer Research : CR·Shaojuan YuKun Yang
Jul 15, 2015·Oncotarget·Morten F GjerstorffHenrik J Ditzel
Aug 11, 2015·The Journal of Clinical Investigation·Matthew M GubinRobert D Schreiber
Feb 26, 2016·Asian Journal of Andrology·Steven M MooneyPrakash Kulkarni

❮ Previous
Next ❯

Citations

Oct 20, 2018·International Journal of Cancer. Journal International Du Cancer·Jing ChenBing Wang
Jun 27, 2019·Cells·Patti OlusolaSantanu Dasgupta
Dec 14, 2018·Oncoimmunology·Lucillia BezuLorenzo Galluzzi
Sep 8, 2020·The Journal of Gene Medicine·Weisheng WangYong Li
Jun 26, 2020·Frontiers in Molecular Biosciences·Shuya YangKun Yang
Jan 14, 2021·Molecular Biology Reports·Mwichie NamusambaBing Wang
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Xiyang ZhangKun Yang
Apr 29, 2021·Seminars in Cancer Biology·Chunmei FanYong Li
Apr 29, 2021·The Journal of International Medical Research·Fangfang YongHuiqun Jia
May 1, 2021·Biochimie·Esben M Quistgaard
May 15, 2021·Human Vaccines & Immunotherapeutics·Sylvia Annabel DassVenugopal Balakrishnan
Jun 29, 2021·Experimental and Therapeutic Medicine·Haiyan LiangBin Ling
Nov 2, 2021·International Journal of Experimental Pathology·Yan ZhangJingjing Han

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
immunoprecipitation
PCR
RNA-Seq
transfection
xenograft
xenografts
co-immunoprecipitation assay
Co-immunoprecipitation
biopsies

Software Mentioned

GraphPad Prism
Genomic Data Commons
GraphPad
Image J
GSEA
R
SADA
Gene Set Enrichment Analysis ( GSEA )

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.