Bapx1 is required for jaw joint development in amphibians

Evolution & Development
Paul Lukas, Lennart Olsson

Abstract

The acquisition of a movable jaw and a jaw joint are key events in gnathostome evolution. Jaws are derived from the neural crest derived pharyngeal skeleton and the transition from jawless to jawed vertebrates consists of major morphological changes, which must have a genetic foundation. Recent studies on the effects of bapx1 knockdown in fish and chicken indicate that bapx1 has acquired such a role in primary jaw joint development during vertebrate evolution, but evidence from amphibians is missing so far. In the present study, we use Ambystoma mexicanum, Bombina orientalis, and Xenopus laevis to investigate the effects of bapx1 knockdown on the development of these three different amphibians. Using morpholinos we downregulated the expression of bapx1 and obtain morphants with altered mandibular arch morphology. In the absence of bapx1 Meckeĺs cartilage and the palatoquadrate jaw joint initially develop separately but during further development the joint cavity between both fills with chondrocytes. This results in the fusion of both cartilages and the loss of the jaw joint. Despite this the jaw itself remains usable for feeding and breathing. We show that bapx1 plays a role in jaw joint maintenance during development and that ...Continue Reading

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Sep 30, 2017·Journal of Morphology·Paul Lukas, Lennart Olsson

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Citations

May 10, 2020·Journal of Morphology·Paul Lukas, Lennart Olsson
Jun 13, 2020·The Journal of Experimental Biology·Tetsuto MiyashitaW Ted Allison
Apr 28, 2021·Molecular Biology and Evolution·Christine HirschbergerJ Andrew Gillis
Aug 20, 2021·PloS One·Laura WaldmannTatjana Haitina

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