Barbaloin inhibits ventricular arrhythmias in rabbits by modulating voltage-gated ion channels

Acta Pharmacologica Sinica
Zhenzhen CaoJihua Ma

Abstract

Barbaloin (10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone) is extracted from the aloe plant and has been reported to have anti-inflammatory, antitumor, antibacterial, and other biological activities. Here, we investigated the effects of barbaloin on cardiac electrophysiology, which has not been reported thus far. Cardiac action potentials (APs) and ionic currents were recorded in isolated rabbit ventricular myocytes using whole-cell patch-clamp technique. Additionally, the antiarrhythmic effect of barbaloin was examined in Langendorff-perfused rabbit hearts. In current-clamp recording, application of barbaloin (100 and 200 μmol/L) dose-dependently reduced the action potential duration (APD) and the maximum depolarization velocity (Vmax), and attenuated APD reverse-rate dependence (RRD) in ventricular myocytes. Furthermore, barbaloin (100 and 200 μmol/L) effectively eliminated ATX II-induced early afterdepolarizations (EADs) and Ca2+-induced delayed afterdepolarizations (DADs) in ventricular myocytes. In voltage-clamp recording, barbaloin (10-200 μmol/L) dose-dependently inhibited L-type calcium current (ICa.L) and peak sodium current (INa.P) with IC50 values of 137.06 and 559.80 μmol/L, respectively. ...Continue Reading

References

May 1, 1997·The Journal of Physiology·C A Ward, W R Giles
Aug 23, 2003·Circulation Research·Fadi G Akar, David S Rosenbaum
Nov 19, 2003·American Journal of Therapeutics·Luigi X Cubeddu
May 1, 2004·Critical Reviews in Food Science and Nutrition·Kojo Eshun, Qian He
Feb 19, 2005·Circulation Research·Rodolphe P Katra, Kenneth R Laurita
Sep 27, 2005·Physiological Reviews·Jeanne M Nerbonne, Robert S Kass
Jun 2, 2007·Circulation Research·Kirsten H W J Ten TusscherAlexander V Panfilov
Jun 26, 2007·Acta Pharmacologica Sinica·Marco Santonastasi, Xander H T Wehrens
Jul 20, 2007·Journal of the American College of Nutrition·Rosanna Y Y LamChristopher H K Cheng
Oct 16, 2008·Cardiovascular & Hematological Agents in Medicinal Chemistry·Albertas Undrovinas, Victor A Maltsev
Nov 29, 2008·Circulation Research·Lai-Hua XieJames N Weiss
Oct 31, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ahmad S AminArthur A M Wilde
Feb 11, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tao XuDe-Ning Liao
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·D K PatelV Tahilyani
Jun 12, 2013·Cardiovascular Research·John C ShryockLuiz Belardinelli
Nov 28, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhenying ZhaoGuo'an Luo
Dec 11, 2013·Nature Reviews. Cardiology·Roos F MarsmanConnie R Bezzina
Apr 1, 2014·Journal of Photochemistry and Photobiology. B, Biology·Mariane Arnoldi SilvaJuliano Ferreira
Apr 17, 2014·Handbook of Experimental Pharmacology·David K Jones, Peter C Ruben
Oct 22, 2014·Scandinavian Cardiovascular Journal : SCJ·Oleg E Osadchii
Mar 10, 2016·Asian-Australasian Journal of Animal Sciences·Arun K DasS Biswas
Oct 30, 2016·European Journal of Pharmacology·Sheng-Na HanLi-Rong Zhang
Dec 13, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Mauricio PimentelLuis E Rohde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.