Barberry administration and pro-oxidant-antioxidant balance in patients with metabolic syndrome

Iranian Red Crescent Medical Journal
Akram MohammadiMajid Ghayour Mobarhan

Abstract

Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant-antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD. This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome. A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention. There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01). Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.

References

Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Aug 5, 1999·Experimental Gerontology·B T Ashok, R Ali
Apr 17, 2001·Bioscience, Biotechnology, and Biochemistry·D S ChoiM Y Jung
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Apr 22, 2004·The Journal of Pharmacy and Pharmacology·Takako YokozawaYasumasa Ikeshiro
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Annie ShirwaikarIsaac Sam Raj Punitha
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy
Mar 22, 2008·BMJ : British Medical Journal·Edwin A M Gale
Apr 24, 2009·Archives of Pharmacal Research·Moon Hee JangJeong Hill Park
May 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Zovko KoncićI Kosalec
Oct 19, 2011·International Journal of Dermatology·Mohammad Javad YazdanpanahAmirhossein Sahebkar
Jul 19, 2012·Fitoterapia·Dipti PotdarSivakami Dhulap
Nov 1, 2013·Science China. Life Sciences·Jing YaoJianDong Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
ELISA
MDA

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.