PMID: 7334373Dec 1, 1981Paper

Barbiturate attenuation of brain free fatty acid liberation during global ischemia

Journal of Neurochemistry
G K Shiu, E M Nemoto

Abstract

To find a biochemical basis for the increased tolerance of the brain to anoxia during barbiturate anesthesia, we studied whole-brain free fatty acids (FFA) at various times after decapitation of awake and pentobarbital-anesthetized rats. Post-decapitation, the brains were kept at 37 degrees C for 1 to 60 min before freezing in liquid N2. Nonischemic brains were frozen in liquid N2, using a rapid sampling technique. Whole-brain arachidonic, stearic, oleic, linoleic, and palmitic acids were quantitated by gas-liquid chromatography. In unanesthetized, nonischemic brain, total FFA was 1226 +/- 121 nmol/g brain (n = 12) and was unaffected by pentobarbital anesthesia (1126 +/- 86 nmol/g brain, n = 11), except for a reduction in arachidonic acid. Total FFA in unanesthetized and pentobarbital-anesthetized rats transiently declined between 0 and 1 min of ischemia, and then rose linearly for up to 60 min, with consistently lower values in pentobarbital-treated rats, the greatest attenuation being that of arachidonic and stearic acid liberation. Brain FFA liberation during global ischemia is the first known biochemical variable directly correlated with the duration (i.e., severity) of global ischemia. The attenuation of brain FFA liberati...Continue Reading

References

Apr 1, 1979·Annals of Neurology·P A SteenJ D Michenfelder
Dec 1, 1978·Anesthesiology·A L BleyaertG R Rao
May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Nov 1, 1979·Stroke; a Journal of Cerebral Circulation·J M Hallenbeck, T W Furlow
Sep 1, 1977·Stroke; a Journal of Cerebral Circulation·E M NemotoP Safar
Mar 1, 1979·Stroke; a Journal of Cerebral Circulation·B D SnyderJ H Sung
Nov 1, 1978·Stroke; a Journal of Cerebral Circulation·T W Furlow, J M Hallenbeck
Jan 1, 1975·Stroke; a Journal of Cerebral Circulation·J V SnyderP Safar
Jan 1, 1975·Stroke; a Journal of Cerebral Circulation·J T HoffS L Nielsen
Dec 1, 1973·Archives of Neurology·J B BrierleyA W Brown
Aug 1, 1971·Journal of Neurochemistry·N G BazanC D Joel
Nov 1, 1971·Stroke; a Journal of Cerebral Circulation·F M Yatsu, S A Moss
Nov 1, 1972·The American Journal of Physiology·D H HinzenH Hirsch
Nov 28, 1973·Pflügers Archiv : European journal of physiology·G Gercken, C Bräuning
Jan 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H Woelk, G Porcellati
Jul 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H WoelkG Porcellati
Jan 1, 1974·Stroke; a Journal of Cerebral Circulation·A L SmithC P Larson
Jun 20, 1974·Brain Research·B LjunggrenB K Siesjö
Jul 1, 1968·Biochimica Et Biophysica Acta·G G Lunt, C E Rowe
Jan 1, 1971·Experimental Neurology·L R WolinN Taslitz
Jan 1, 1981·Stroke; a Journal of Cerebral Circulation·E M Nemoto, S Frinak

❮ Previous
Next ❯

Citations

Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·I HamamotoS Todo
Jan 1, 1993·Molecular and Chemical Neuropathology·M ChavkoJ A Melick
Aug 19, 1985·Brain Research·A S KimesS I Rapoport
Jul 1, 1989·Surgical Neurology·J I AusmanG Balakrishnan
Feb 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·J MrsićJ Varljen
Jan 25, 2006·Journal of Neurotrauma·Kimberly D StatlerPatrick M Kochanek
May 1, 1993·Molecular and Chemical Neuropathology·E M Nemoto, M Chavko
Dec 3, 2014·Journal of Pharmacological and Toxicological Methods·Fredrik JernerénOskar Karlsson
Sep 1, 1983·The American Journal of Emergency Medicine·E M NemotoA L Bleyaert
Sep 1, 1983·The American Journal of Emergency Medicine·P Safar
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·G Y Sun, A Y Sun
Mar 28, 2007·Asian Cardiovascular & Thoracic Annals·Yuji Kadoi
Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A Hossmann
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KatsuraB K Siesjö
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E M NemotoA L Bleyaert
Jun 1, 1988·Stroke; a Journal of Cerebral Circulation·Y GotoM Kito
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·M Chavko, E M Nemoto
Jul 1, 1985·Journal of Neurochemistry·H YasudaM Nakanishi
Jul 1, 1984·Journal of Neurochemistry·M F Pediconi, E B Rodríguez de Turco
Nov 1, 1996·Neurosurgery·C L TaylorR A Ratcheson
Oct 3, 1999·Physiological Reviews·P Lipton
May 1, 1994·Survey of Ophthalmology·K D Steinsapir, R A Goldberg
Dec 1, 1988·Analytical Biochemistry·K Kishiro, H Yasuda

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