Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review.

Drug Development Research
Parteek PrasherDevendra S Rawat

Abstract

Development and progression of metastasis comprises synchronized erroneous expressions of several composite pathways, which are difficult to manage simultaneously with the representative anticancer molecules. The emergence of the drug resistance and the complex interplay between these pathways further potentiates cancer related complexities. Barbiturates and their derivatives present a commendable anticancer profile by attenuating the cancer manifesting metabolic and enzymatic pathways including, but not limited to matrix metalloproteinases, xanthine oxidase, amino peptidases, histone deacetylases, and Ras/mitogen-activated protein kinase. The derivatization and conjugation of barbiturates with pharmacophores delivers a suitable hybrid profile in containing the anomalous expression of these pathways. The present report presents a succinct collation of the barbiturates and their derivatives in managing the various cancer causing pathways.

References

Sep 1, 1967·Journal of Medicinal Chemistry·C Hansch, S M Anderson
Jul 23, 1999·Annals of the New York Academy of Sciences·A H DrummondA Wright
Nov 27, 2002·Clinical Colorectal Cancer·Michal G RoseJohn C Schmitz
Dec 14, 2004·Biochimica Et Biophysica Acta·Olaf R F MookCornelis J F Van Noorden
Apr 29, 2005·Journal of Medicinal Chemistry·Hans-Jörg BreyholzKlaus Kopka
Jan 3, 2006·Biochimica Et Biophysica Acta·Ponniah SelvakumarRajendra K Sharma
Feb 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jieyi WangRandy L Bell
Mar 18, 2008·Bioorganic & Medicinal Chemistry Letters·Manas K HaldarSanku Mallik
Apr 10, 2008·Bioconjugate Chemistry·Andreas FaustChristoph Bremer
Jul 19, 2011·Bioorganic & Medicinal Chemistry·Jun WangJohn F Gilmer
Sep 24, 2011·Genes & Cancer·Laia Bosch-Presegué, Alejandro Vaquero
Jan 18, 2012·Journal of Medicinal Chemistry·Jun WangJohn F Gilmer
Dec 19, 2012·Bioorganic & Medicinal Chemistry Letters·Jun WangJohn F Gilmer
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Taranjit Singh GujralMarc W Kirschner
Dec 13, 2012·ACS Medicinal Chemistry Letters·Benjamin MaurerManfred Jung
Jun 26, 2014·Future Medicinal Chemistry·Jing HuHening Lin
Jan 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong LiuHan Liang
Apr 1, 2015·Current Pharmaceutical Design·Britton J ErnstOliver Grundmann
Sep 19, 2015·Nature Reviews. Cancer·Angeliki Chalkiadaki, Leonard Guarente
Jan 5, 2016·Expert Opinion on Drug Discovery·Gervais Bérubé
Jan 30, 2016·Oxidative Medicine and Cellular Longevity·Maria Giulia BattelliAndrea Bolognesi
Mar 2, 2016·Current Drug Targets·Ivano AmelioAlexey V Antonov
Sep 28, 2016·Current Pharmaceutical Design·Albert A AntolinBissan Al-Lazikani
Oct 5, 2016·Current Topics in Medicinal Chemistry·Ertan Kucuksayan, Tomris Ozben
Sep 2, 2017·Scientific Reports·Aurelio Moya-GarcíaJuan A G Ranea
May 8, 2018·Molecular Cancer Therapeutics·Arthur WinerPaolo Mignatti
Nov 16, 2018·MedChemComm·Parteek Prasher, Mousmee Sharma
Mar 2, 2019·International Journal of Molecular Sciences·Mhd Anas TomehXiubo Zhao
Sep 20, 2019·MedChemComm·Parteek Prasher, Mousmee Sharma
Apr 1, 2020·European Journal of Medicinal Chemistry·Subha MondalTarun Jha

❮ Previous
Next ❯

Citations

Jun 13, 2021·Drug Development Research·Parteek Prasher, Mousmee Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Anaesthesia
J W Dundee, D W BARRON
Klinische Anästhesiologie und Intensivtherapie
H Bergmann
Clinical Toxicology
H Matthew
Postgraduate Medicine
R S FISHER, H C FREIMUTH
The American Journal of Nursing
I P FROHMAN
© 2021 Meta ULC. All rights reserved