Bare, bio-active and hydrogel-coated coils for endovascular treatment of experimentally induced aneurysms. Long-term histological and scanning electron microscopy results.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
M H T ReingesF J Hans

Abstract

Endovascular treatments of cerebral aneurysms with bare platinum coils have a higher rate of recurrence compared to surgical clipping. This may be related to failed vessel wall reconstruction since histological and scanning electron microscopy results following embolization failed to demonstrate neoendothelialization over the aneurysm neck. The present study tried to elucidate whether the use of modified coils resulted in a better rate of reconstructing the vessel wall over the aneurysm neck in experimental aneurysms. Aneurysms were created in 20 rabbits by intraluminal elastase incubation of the common carotid artery. Five animals each were assigned to the following groups: untreated, bare platinum coils, bioactive coils with polyglycolic/polylactic acid coating, and hydrogel-coated platinum coils. After 12 months, angiography, histology and scanning electron microscopy was performed. No neoendothelial layer was visualized in the bioactive and bare coil groups with a tendency to an increased layering of fibroblasts along the bioactive coils at the aneurysm fundus. However, at the aneurysm neck perfused clefts were present and although a thin fibrinous layer was present over some coils, no bridging neointimal or neoendothial la...Continue Reading

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Citations

Jan 1, 2014·Future Neurology·Joseph S HudsonDavid M Hasan
Nov 3, 2017·Cardiovascular and Interventional Radiology·Audrey FohlenJean-Pierre Pelage
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Apr 24, 2015·Journal of Neurointerventional Surgery·Waleed BrinjikjiRamanathan Kadirvel
Aug 4, 2018·Biomechanics and Modeling in Mechanobiology·John D HornJason M Ortega
Aug 17, 2018·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Yoko UsamiKoh-Ichi Sakata
Oct 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amir DarkiGregory J Mishkel
Sep 4, 2018·Journal of Vascular and Interventional Radiology : JVIR·Audrey FohlenJean-Pierre Pelage

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