Bariatric Surgery for Morbid Obesity: Tehran Obesity Treatment Study (TOTS) Rationale and Study Design

JMIR Research Protocols
Maryam BarzinAlireza Khalaj

Abstract

Obesity is a major health concern in the Middle East and worldwide. It is among the leading causes of morbidity, mortality, health care utilization, and costs. With bariatric surgery proving to be a more effective treatment option for overweight and obesity, the need for systematic assessment of different procedures and their outcomes becomes necessary. These procedures have not yet been described in detail in our region. We aim to undertake a prospective study evaluating and comparing several surgical bariatric procedures in an Iranian population of morbid obese patients presenting to a specialized bariatric center. In order to facilitate and accelerate understanding of obesity and its complications, the Tehran Obesity Treatment Study (TOTS) was planned and developed. This study is a longitudinal prospective cohort study in consecutive patients undergoing bariatric surgery. TOTS investigators use standardized definitions, high-fidelity data collection system, and validated instruments to gather data preoperatively, at the time of surgery, postoperatively, and in longer-term follow-up. This study has recruited 1050 participants as of September 2015 and is ongoing. This study will ensure creation of high-level evidence to enable...Continue Reading

References

Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Oct 9, 2001·The Surgical Clinics of North America·T A WaddenA Schimmel
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Aug 21, 2004·Annals of Surgery·Nicolas V ChristouLloyd D MacLean
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Apr 6, 2005·Annals of Internal Medicine·Melinda A MaggardPaul G Shekelle
Aug 3, 2005·Depression and Anxiety·Habibollah GhassemzadehNarges Ebrahimkhani
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Aug 24, 2007·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Anoop Misra, Lokesh Khurana
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Jul 31, 2009·The New England Journal of Medicine·UNKNOWN Longitudinal Assessment of Bariatric Surgery (LABS) ConsortiumBruce Wolfe
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Ted D AdamsSteven C Hunt
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Aug 12, 2014·The Cochrane Database of Systematic Reviews·Jill L ColquittGeoff K Frampton
Aug 29, 2014·BMJ : British Medical Journal·David E Arterburn, Anita P Courcoulas
Sep 4, 2014·JAMA : the Journal of the American Medical Association·Nancy PuzziferriEdward H Livingston
Jun 1, 2000·Research Quarterly for Exercise and Sport·M Booth

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Citations

Mar 11, 2017·International Journal of Surgery Case Reports·Mohammad Ali Kalantar MotamediAlireza Khalaj
Feb 11, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Firoozeh Hosseini-EsfahaniParvin Mirmiran
Dec 26, 2018·International Journal of Endocrinology and Metabolism·Maryam BarzinFarhad Hosseinpanah
Jun 19, 2021·Scientific Reports·Pouria MousapourMaryam Barzin
Jul 18, 2021·Eating and Weight Disorders : EWD·Habib YarizadehKhadijeh Mirzaei
Sep 22, 2021·Journal of Public Health Research·Farhad PourfarziFirouz Amani

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Methods Mentioned

BETA
gastric bypass
urine collection

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